HFLD_ECOL6
ID HFLD_ECOL6 Reviewed; 213 AA.
AC Q8FIB7;
DT 15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=High frequency lysogenization protein HflD {ECO:0000255|HAMAP-Rule:MF_00695};
GN Name=hflD {ECO:0000255|HAMAP-Rule:MF_00695}; OrderedLocusNames=c1511;
OS Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=199310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFT073 / ATCC 700928 / UPEC;
RX PubMed=12471157; DOI=10.1073/pnas.252529799;
RA Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA Donnenberg M.S., Blattner F.R.;
RT "Extensive mosaic structure revealed by the complete genome sequence of
RT uropathogenic Escherichia coli.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC -!- FUNCTION: Negative regulator of phage lambda lysogenization.
CC Contributes to the degradation of the phage regulatory protein CII.
CC Acts probably by holding CII on the membrane surface, away from the
CC target promoters, but close to the FtsH protease. {ECO:0000255|HAMAP-
CC Rule:MF_00695}.
CC -!- SUBUNIT: Interacts with CII protein from phage lambda.
CC {ECO:0000255|HAMAP-Rule:MF_00695}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane
CC {ECO:0000255|HAMAP-Rule:MF_00695}; Peripheral membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_00695}; Cytoplasmic side {ECO:0000255|HAMAP-
CC Rule:MF_00695}.
CC -!- SIMILARITY: Belongs to the HflD family. {ECO:0000255|HAMAP-
CC Rule:MF_00695}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN79980.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE014075; AAN79980.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_001295971.1; NC_004431.1.
DR AlphaFoldDB; Q8FIB7; -.
DR SMR; Q8FIB7; -.
DR STRING; 199310.c1511; -.
DR EnsemblBacteria; AAN79980; AAN79980; c1511.
DR KEGG; ecc:c1511; -.
DR eggNOG; COG2915; Bacteria.
DR HOGENOM; CLU_098920_0_0_6; -.
DR OMA; RYIISLM; -.
DR Proteomes; UP000001410; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.3890.10; -; 1.
DR HAMAP; MF_00695; HflD_protein; 1.
DR InterPro; IPR007451; HflD.
DR InterPro; IPR035932; HflD-like_sf.
DR PANTHER; PTHR38100; PTHR38100; 1.
DR Pfam; PF04356; DUF489; 1.
DR SUPFAM; SSF101322; SSF101322; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Coiled coil; Cytoplasm; Membrane.
FT CHAIN 1..213
FT /note="High frequency lysogenization protein HflD"
FT /id="PRO_0000071577"
FT COILED 79..126
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00695"
SQ SEQUENCE 213 AA; 22934 MW; 71C8F96F8EAA37BB CRC64;
MAKNYYDITL ALAGICQSAR LVQQLAHQGH CDGDALHVSL NSIIDMNPSS TLAVFGGSEA
NLRVGLETLL GVLNASSRQG LNAELTRYTL SLMVLERKLS SAKGALDTLG NRINGLQRQL
EHFDLQSETL MSAMAAIYVD VISPLGPRIQ VTGSPAVLQS PQVQAKVRAT LLAGIRAAVL
WHQVGGGRLQ LMFSRNRLTT QAKQILAHLT PEL