ID   HFLD_ECOSM              Reviewed;         213 AA.
AC   B1LI11;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=High frequency lysogenization protein HflD {ECO:0000255|HAMAP-Rule:MF_00695};
GN   Name=hflD {ECO:0000255|HAMAP-Rule:MF_00695};
GN   OrderedLocusNames=EcSMS35_1993;
OS   Escherichia coli (strain SMS-3-5 / SECEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=439855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS-3-5 / SECEC;
RX   PubMed=18708504; DOI=10.1128/jb.00661-08;
RA   Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA   Ravel J., Stepanauskas R.;
RT   "Insights into the environmental resistance gene pool from the genome
RT   sequence of the multidrug-resistant environmental isolate Escherichia coli
RT   SMS-3-5.";
RL   J. Bacteriol. 190:6779-6794(2008).
CC   -!- FUNCTION: Negative regulator of phage lambda lysogenization.
CC       Contributes to the degradation of the phage regulatory protein CII.
CC       Acts probably by holding CII on the membrane surface, away from the
CC       target promoters, but close to the FtsH protease. {ECO:0000255|HAMAP-
CC       Rule:MF_00695}.
CC   -!- SUBUNIT: Interacts with CII protein from phage lambda.
CC       {ECO:0000255|HAMAP-Rule:MF_00695}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane
CC       {ECO:0000255|HAMAP-Rule:MF_00695}; Peripheral membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_00695}; Cytoplasmic side {ECO:0000255|HAMAP-
CC       Rule:MF_00695}.
CC   -!- SIMILARITY: Belongs to the HflD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00695}.
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DR   EMBL; CP000970; ACB17949.1; -; Genomic_DNA.
DR   RefSeq; WP_001295971.1; NC_010498.1.
DR   AlphaFoldDB; B1LI11; -.
DR   SMR; B1LI11; -.
DR   EnsemblBacteria; ACB17949; ACB17949; EcSMS35_1993.
DR   KEGG; ecm:EcSMS35_1993; -.
DR   HOGENOM; CLU_098920_0_0_6; -.
DR   OMA; RYIISLM; -.
DR   Proteomes; UP000007011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.3890.10; -; 1.
DR   HAMAP; MF_00695; HflD_protein; 1.
DR   InterPro; IPR007451; HflD.
DR   InterPro; IPR035932; HflD-like_sf.
DR   PANTHER; PTHR38100; PTHR38100; 1.
DR   Pfam; PF04356; DUF489; 1.
DR   SUPFAM; SSF101322; SSF101322; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Coiled coil; Cytoplasm; Membrane.
FT   CHAIN           1..213
FT                   /note="High frequency lysogenization protein HflD"
FT                   /id="PRO_1000132289"
FT   COILED          79..126
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00695"
SQ   SEQUENCE   213 AA;  22934 MW;  71C8F96F8EAA37BB CRC64;
     MAKNYYDITL ALAGICQSAR LVQQLAHQGH CDGDALHVSL NSIIDMNPSS TLAVFGGSEA
     NLRVGLETLL GVLNASSRQG LNAELTRYTL SLMVLERKLS SAKGALDTLG NRINGLQRQL
     EHFDLQSETL MSAMAAIYVD VISPLGPRIQ VTGSPAVLQS PQVQAKVRAT LLAGIRAAVL
     WHQVGGGRLQ LMFSRNRLTT QAKQILAHLT PEL