HFLD_ESCF3
ID HFLD_ESCF3 Reviewed; 213 AA.
AC B7LSM7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=High frequency lysogenization protein HflD {ECO:0000255|HAMAP-Rule:MF_00695};
GN Name=hflD {ECO:0000255|HAMAP-Rule:MF_00695}; OrderedLocusNames=EFER_1798;
OS Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 / JCM
RC 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Negative regulator of phage lambda lysogenization.
CC Contributes to the degradation of the phage regulatory protein CII.
CC Acts probably by holding CII on the membrane surface, away from the
CC target promoters, but close to the FtsH protease. {ECO:0000255|HAMAP-
CC Rule:MF_00695}.
CC -!- SUBUNIT: Interacts with CII protein from phage lambda.
CC {ECO:0000255|HAMAP-Rule:MF_00695}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Cell inner membrane
CC {ECO:0000255|HAMAP-Rule:MF_00695}; Peripheral membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_00695}; Cytoplasmic side {ECO:0000255|HAMAP-
CC Rule:MF_00695}.
CC -!- SIMILARITY: Belongs to the HflD family. {ECO:0000255|HAMAP-
CC Rule:MF_00695}.
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DR EMBL; CU928158; CAQ89313.1; -; Genomic_DNA.
DR RefSeq; WP_001297479.1; NC_011740.1.
DR AlphaFoldDB; B7LSM7; -.
DR SMR; B7LSM7; -.
DR EnsemblBacteria; CAQ89313; CAQ89313; EFER_1798.
DR GeneID; 67414325; -.
DR KEGG; efe:EFER_1798; -.
DR HOGENOM; CLU_098920_0_0_6; -.
DR OMA; RYIISLM; -.
DR OrthoDB; 870739at2; -.
DR BioCyc; EFER585054:EFER_RS09040-MON; -.
DR Proteomes; UP000000745; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.3890.10; -; 1.
DR HAMAP; MF_00695; HflD_protein; 1.
DR InterPro; IPR007451; HflD.
DR InterPro; IPR035932; HflD-like_sf.
DR PANTHER; PTHR38100; PTHR38100; 1.
DR Pfam; PF04356; DUF489; 1.
DR SUPFAM; SSF101322; SSF101322; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Coiled coil; Cytoplasm; Membrane.
FT CHAIN 1..213
FT /note="High frequency lysogenization protein HflD"
FT /id="PRO_1000132291"
FT COILED 79..126
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00695"
SQ SEQUENCE 213 AA; 22948 MW; E26EF9698C3CEE42 CRC64;
MAKNYYDITL ALAGICQSAR LVQQLAHQGH CDADALHVSL NSIIDMNPSS TLAVFGGSEA
NLRVGLETLL GVLNASSRQG LNAELTRYTL SLMVLERKLS SAKGALDTLG NRINGLQRQL
EHFDLQSETL MSAMAAIYVD VISPLGPRIQ VTGSPAVLQS PQVQAKVRAT LLAGIRAAVL
WHQVGGGRLQ LMFSRNRLTT QAKQILAHLT PEL
