HFLK_HAEIN
ID HFLK_HAEIN Reviewed; 410 AA.
AC P44546;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein HflK;
GN Name=hflK; OrderedLocusNames=HI_0151;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: HflC and HflK could encode or regulate a protease.
CC {ECO:0000250}.
CC -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflK subfamily.
CC {ECO:0000305}.
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DR EMBL; L42023; AAC21822.1; -; Genomic_DNA.
DR PIR; A64051; A64051.
DR RefSeq; NP_438321.1; NC_000907.1.
DR AlphaFoldDB; P44546; -.
DR SMR; P44546; -.
DR STRING; 71421.HI_0151; -.
DR PRIDE; P44546; -.
DR EnsemblBacteria; AAC21822; AAC21822; HI_0151.
DR KEGG; hin:HI_0151; -.
DR PATRIC; fig|71421.8.peg.154; -.
DR eggNOG; COG0330; Bacteria.
DR HOGENOM; CLU_039173_1_0_6; -.
DR OMA; WNEPGGN; -.
DR PhylomeDB; P44546; -.
DR BioCyc; HINF71421:G1GJ1-163-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR CDD; cd03404; SPFH_HflK; 1.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR010201; HflK.
DR InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR PANTHER; PTHR43327:SF2; PTHR43327:SF2; 1.
DR Pfam; PF01145; Band_7; 1.
DR PRINTS; PR00721; STOMATIN.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
DR TIGRFAMs; TIGR01933; hflK; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..410
FT /note="Protein HflK"
FT /id="PRO_0000094087"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 45806 MW; FB6CCD1AF44FA09C CRC64;
MENEMSQNGS DRDPWSKPGQ SNDQQPGNSS NNNGWNNNQN RGNQEQSPPD IEEIFNNLLK
KLGGGNKKSG QNNGSSQGNT PFHFGKVIPL AVAIGAIIWG VNGFYTIKEA ERGVVLRFGE
LHSIVQPGLN WKPTFVDKVL PVNVEQVKEL RTQGAMLTQD ENMVKVEMTV QYRVQDPAKY
LFSVTNADDS LNQATDSALR YVIGHMSMND ILTTGRSVVR ENTWKALNEI IKSYDMGLEV
IDVNFQSARP PEEVKDAFDD AIKAQEDEQR FIREAEAYAR EKEPIARGDA QRILEEATAY
KDRIVLDAKG EVERLQRLLP EFKAAPDLLR ERLYIQTMEK VMANTPKVML DGNNGNNLTV
LPLEQIMGKK SVTSAPSAVN SSPAFTAPER QNSYQPQPTT VAPIRQGRFN
