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HFLK_TREPA
ID   HFLK_TREPA              Reviewed;         328 AA.
AC   O83151;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Protein HflK;
GN   Name=hflK; OrderedLocusNames=TP_0113;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: HflC and HflK could encode or regulate a protease.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE000520; AAC65102.1; -; Genomic_DNA.
DR   PIR; H71364; H71364.
DR   RefSeq; WP_010881562.1; NC_021490.2.
DR   AlphaFoldDB; O83151; -.
DR   IntAct; O83151; 5.
DR   STRING; 243276.TPANIC_0113; -.
DR   EnsemblBacteria; AAC65102; AAC65102; TP_0113.
DR   KEGG; tpa:TP_0113; -.
DR   eggNOG; COG0330; Bacteria.
DR   HOGENOM; CLU_039173_0_1_12; -.
DR   OMA; WNEPGGN; -.
DR   OrthoDB; 577287at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd03404; SPFH_HflK; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR010201; HflK.
DR   PANTHER; PTHR43327:SF2; PTHR43327:SF2; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   TIGRFAMs; TIGR01933; hflK; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Protein HflK"
FT                   /id="PRO_0000094088"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   328 AA;  36967 MW;  F6CDDBAA5DC20B31 CRC64;
     MRIPKWTPAT WSVVAGCIGG VLGIVIVGIA SPIRIISPTD NGVVTRFGKY HRTLEPGLHY
     LIPFVEWVYK VPVTKVQKEE FGFRTSKSSE QSHYVNNISH ESLMLTGDLN IVDVEWVVQY
     RIVDPRAWVF NVESQERRQT IRDISKAVVN SLIGDRAILD IMGPERSAIQ MRAKDMMNVL
     LKRIGLGVLV SSVQLQNVVP PQEVQQAFED VNIAIQDMNR LINEGKESYN REIPKARGDA
     DKLIQEAMGY ANERVNRAKG DVARFDSIYA EYVKAPHVTK TRLYLEGLGA ILEKTENVLL
     IDKKLENLLT LKDISKVSKK VVAGTREE
 
 
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