ID   HFLK_VIBCH              Reviewed;         395 AA.
AC   Q9KV09;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein HflK;
GN   Name=hflK; OrderedLocusNames=VC_0349;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: HflC and HflK could encode or regulate a protease.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE003852; AAF93522.1; -; Genomic_DNA.
DR   PIR; E82334; E82334.
DR   RefSeq; NP_230003.1; NC_002505.1.
DR   RefSeq; WP_000312460.1; NZ_LT906614.1.
DR   AlphaFoldDB; Q9KV09; -.
DR   SMR; Q9KV09; -.
DR   STRING; 243277.VC_0349; -.
DR   DNASU; 2615062; -.
DR   EnsemblBacteria; AAF93522; AAF93522; VC_0349.
DR   GeneID; 57739086; -.
DR   KEGG; vch:VC_0349; -.
DR   PATRIC; fig|243277.26.peg.326; -.
DR   eggNOG; COG0330; Bacteria.
DR   HOGENOM; CLU_039173_1_0_6; -.
DR   OMA; WNEPGGN; -.
DR   BioCyc; VCHO:VC0349-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   CDD; cd03404; SPFH_HflK; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR010201; HflK.
DR   InterPro; IPR020980; Membrane_HflK_N.
DR   InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR   PANTHER; PTHR43327:SF2; PTHR43327:SF2; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   Pfam; PF12221; HflK_N; 1.
DR   PRINTS; PR00721; STOMATIN.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   TIGRFAMs; TIGR01933; hflK; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..395
FT                   /note="Protein HflK"
FT                   /id="PRO_0000094089"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          352..395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        355..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   395 AA;  43815 MW;  6748952005388D94 CRC64;
     MAWNEPGNNN GNNGRDNDPW GNNNRGNKGG RDQGPPDLDE VFNKLSQKLG GKFGGKGGKG
     PSFSGGGAIG FGVIAAIAVA VWFFTGFYTI GEAERGVVLR LGKYDRIVDP GLNWRPRFID
     EVTPVNVQAI RSLRASGLML TKDENVVTVS MDVQYRIADP YKYLYRVTNA DDSLRQATDS
     ALRAVVGDSL MDSILTSGRQ QIRQSTQQTL NQVIDSYDMG LMIVDVNFQS ARPPEQVKDA
     FDDAIAARED EERFIREAEA YKNEILPKAT GRAERLKKEA QGYNERTINE ALGQVAQFEK
     LLPEYQAAPK VTRDRLYLDA MEQVYSNTSK VLIDSESSGN LLYLPIDKLA GQDNKTAQPR
     PNKSSSAYDQ IELESQTTET NTDTQSRSTT RQGRY