ID   HFLK_VIBPA              Reviewed;         400 AA.
AC   P40605;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Protein HflK;
GN   Name=hflK; OrderedLocusNames=VP2815;
OS   Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=223926;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BB22;
RA   McCarter L.L.;
RL   Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RIMD 2210633;
RX   PubMed=12620739; DOI=10.1016/s0140-6736(03)12659-1;
RA   Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA   Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA   Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT   "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT   distinct from that of V. cholerae.";
RL   Lancet 361:743-749(2003).
CC   -!- FUNCTION: HflC and HflK could encode or regulate a protease.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflK subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U09005; AAA62186.1; -; Genomic_DNA.
DR   EMBL; BA000031; BAC61078.1; -; Genomic_DNA.
DR   RefSeq; NP_799194.1; NC_004603.1.
DR   RefSeq; WP_005460667.1; NC_004603.1.
DR   AlphaFoldDB; P40605; -.
DR   SMR; P40605; -.
DR   STRING; 223926.28807825; -.
DR   EnsemblBacteria; BAC61078; BAC61078; BAC61078.
DR   GeneID; 1190365; -.
DR   KEGG; vpa:VP2815; -.
DR   PATRIC; fig|223926.6.peg.2706; -.
DR   eggNOG; COG0330; Bacteria.
DR   HOGENOM; CLU_039173_1_0_6; -.
DR   OMA; WNEPGGN; -.
DR   Proteomes; UP000002493; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd03404; SPFH_HflK; 1.
DR   Gene3D; 3.30.479.30; -; 1.
DR   InterPro; IPR001107; Band_7.
DR   InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR   InterPro; IPR010201; HflK.
DR   InterPro; IPR020980; Membrane_HflK_N.
DR   InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR   PANTHER; PTHR43327:SF2; PTHR43327:SF2; 1.
DR   Pfam; PF01145; Band_7; 1.
DR   Pfam; PF12221; HflK_N; 1.
DR   PRINTS; PR00721; STOMATIN.
DR   SMART; SM00244; PHB; 1.
DR   SUPFAM; SSF117892; SSF117892; 1.
DR   TIGRFAMs; TIGR01933; hflK; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..400
FT                   /note="Protein HflK"
FT                   /id="PRO_0000094090"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..400
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..370
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..400
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  44237 MW;  B94D8363FD81DC84 CRC64;
     MAWNEPGNNN GNNGRDNDPW GNNNRGGQRP GGRDQGPPDL DEVFNKLSQK LGGKFGKKGG
     GGSSIGGGGG AIGFGVIAII AIAVWIFAGF YTIGEAERGV VLRLGKYDRI VDPGLNWRPR
     FIDEYEAVNV QAIRSLRASG LMLTKDENVV TVAMDVQYRV ADPYKYLYRV TNADDSLRQA
     TDSALRAVIG DSLMDSILTS GRQQIRQSTQ ETLNQIIDSY DMGLVIVDVN FQSARPPEQV
     KDAFDDAIAA REDEERFIRE AEAYKNEILP KATGRAERLK KEAQGYNERV TNEALGQVAQ
     FEKLLPEYQA APGVTRDRLY IDAMEEVYTN TSKVLIDSES SGNLLYLPID KLAGQEGQTD
     TKRKSKSSST YDHIQLESER TQEETSNTQS RSTGTRQGRY