ID   HFQ_AZOC5               Reviewed;          85 AA.
AC   Q43971; A8IBJ6;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule:MF_00436};
GN   Name=hfq {ECO:0000255|HAMAP-Rule:MF_00436}; Synonyms=nfrA;
GN   OrderedLocusNames=AZC_3080;
OS   Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG
OS   6465 / NBRC 14845 / NCIMB 13405 / ORS 571).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Xanthobacteraceae; Azorhizobium.
OX   NCBI_TaxID=438753;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=8197116; DOI=10.1073/pnas.91.11.4663;
RA   Kaminski P.A., Desnoues N., Elmerich C.;
RT   "The expression of nifA in Azorhizobium caulinodans requires a gene product
RT   homologous to Escherichia coli HF-I, an RNA-binding protein involved in the
RT   replication of phage Q beta RNA.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:4663-4667(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB
RC   13405 / ORS 571;
RA   Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T.,
RA   Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B.,
RA   Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.;
RT   "Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium
RT   caulinodans ORS571.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and
CC       mRNAs to facilitate mRNA translational regulation in response to
CC       envelope stress, environmental stress and changes in metabolite
CC       concentrations. Also binds with high specificity to tRNAs (By
CC       similarity). Seems to be involved in the regulation of NifA.
CC       {ECO:0000255|HAMAP-Rule:MF_00436, ECO:0000269|PubMed:8197116}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00436}.
CC   -!- SIMILARITY: Belongs to the Hfq family. {ECO:0000255|HAMAP-
CC       Rule:MF_00436}.
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DR   EMBL; X76450; CAA53989.1; -; Genomic_DNA.
DR   EMBL; AP009384; BAF89078.1; -; Genomic_DNA.
DR   PIR; I39519; I39519.
DR   RefSeq; WP_012171604.1; NC_009937.1.
DR   AlphaFoldDB; Q43971; -.
DR   SMR; Q43971; -.
DR   STRING; 438753.AZC_3080; -.
DR   EnsemblBacteria; BAF89078; BAF89078; AZC_3080.
DR   KEGG; azc:AZC_3080; -.
DR   eggNOG; COG1923; Bacteria.
DR   HOGENOM; CLU_113688_0_0_5; -.
DR   OMA; QQMVYKH; -.
DR   OrthoDB; 1989988at2; -.
DR   Proteomes; UP000000270; Chromosome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01716; Hfq; 1.
DR   HAMAP; MF_00436; Hfq; 1.
DR   InterPro; IPR005001; Hfq.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   PANTHER; PTHR34772; PTHR34772; 1.
DR   Pfam; PF17209; Hfq; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   TIGRFAMs; TIGR02383; Hfq; 1.
PE   3: Inferred from homology;
KW   Reference proteome; RNA-binding; Stress response.
FT   CHAIN           1..85
FT                   /note="RNA-binding protein Hfq"
FT                   /id="PRO_0000095613"
SQ   SEQUENCE   85 AA;  9621 MW;  CECEC3380DD8C94B CRC64;
     MAAERTQNLQ DTFLNHVRKS KTPLTIFLVN GVKLQGVVTW FDNFCVLLRR DGHSQLVYKH
     AISTIMPGHP VQLFDPTDEV ASEKA