ID   HFQ_BACSU               Reviewed;          73 AA.
AC   O31796;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule:MF_00436};
GN   Name=hfq {ECO:0000255|HAMAP-Rule:MF_00436}; Synonyms=ymaH;
GN   OrderedLocusNames=BSU17340;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and
CC       mRNAs to facilitate mRNA translational regulation in response to
CC       envelope stress, environmental stress and changes in metabolite
CC       concentrations. Also binds with high specificity to tRNAs.
CC       {ECO:0000255|HAMAP-Rule:MF_00436}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00436}.
CC   -!- SIMILARITY: Belongs to the Hfq family. {ECO:0000255|HAMAP-
CC       Rule:MF_00436}.
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DR   EMBL; AL009126; CAB13618.1; -; Genomic_DNA.
DR   PIR; B69884; B69884.
DR   RefSeq; NP_389616.1; NC_000964.3.
DR   RefSeq; WP_003221097.1; NZ_JNCM01000035.1.
DR   PDB; 3AHU; X-ray; 2.20 A; A/B/C=1-73.
DR   PDB; 3HSB; X-ray; 2.20 A; A/B/C/D/E/F=1-73.
DR   PDBsum; 3AHU; -.
DR   PDBsum; 3HSB; -.
DR   AlphaFoldDB; O31796; -.
DR   SMR; O31796; -.
DR   STRING; 224308.BSU17340; -.
DR   PaxDb; O31796; -.
DR   PRIDE; O31796; -.
DR   EnsemblBacteria; CAB13618; CAB13618; BSU_17340.
DR   GeneID; 50133400; -.
DR   GeneID; 64303627; -.
DR   GeneID; 940073; -.
DR   KEGG; bsu:BSU17340; -.
DR   PATRIC; fig|224308.179.peg.1880; -.
DR   eggNOG; COG1923; Bacteria.
DR   InParanoid; O31796; -.
DR   OMA; QQMVYKH; -.
DR   PhylomeDB; O31796; -.
DR   BioCyc; BSUB:BSU17340-MON; -.
DR   EvolutionaryTrace; O31796; -.
DR   PRO; PR:O31796; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0043487; P:regulation of RNA stability; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0045974; P:regulation of translation, ncRNA-mediated; IBA:GO_Central.
DR   CDD; cd01716; Hfq; 1.
DR   HAMAP; MF_00436; Hfq; 1.
DR   InterPro; IPR005001; Hfq.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   PANTHER; PTHR34772; PTHR34772; 1.
DR   Pfam; PF17209; Hfq; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   TIGRFAMs; TIGR02383; Hfq; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; RNA-binding; Stress response.
FT   CHAIN           1..73
FT                   /note="RNA-binding protein Hfq"
FT                   /id="PRO_0000095621"
FT   HELIX           6..17
FT                   /evidence="ECO:0007829|PDB:3AHU"
FT   STRAND          21..25
FT                   /evidence="ECO:0007829|PDB:3AHU"
FT   STRAND          30..38
FT                   /evidence="ECO:0007829|PDB:3AHU"
FT   STRAND          40..49
FT                   /evidence="ECO:0007829|PDB:3AHU"
FT   STRAND          51..55
FT                   /evidence="ECO:0007829|PDB:3AHU"
FT   HELIX           56..58
FT                   /evidence="ECO:0007829|PDB:3AHU"
FT   STRAND          59..66
FT                   /evidence="ECO:0007829|PDB:3AHU"
SQ   SEQUENCE   73 AA;  8514 MW;  13909E5F41DB3A57 CRC64;
     MKPINIQDQF LNQIRKENTY VTVFLLNGFQ LRGQVKGFDN FTVLLESEGK QQLIYKHAIS
     TFAPQKNVQL ELE