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3SIM4_DENAN
ID   3SIM4_DENAN             Reviewed;          66 AA.
AC   Q9PSN1;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Muscarinic toxin 4;
DE            Short=MT4;
OS   Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Dendroaspis.
OX   NCBI_TaxID=8618;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=8585087; DOI=10.1016/0041-0101(95)00057-s;
RA   Vandermeers A., Vandermeers-Piret M.-C., Rathe J., Waelbroeck M.,
RA   Jolkkonen M., Oras A., Karlsson E.;
RT   "Purification and sequence determination of a new muscarinic toxin (MT4)
RT   from the venom of the green mamba (Dendroaspis angusticeps).";
RL   Toxicon 33:1171-1179(1995).
CC   -!- FUNCTION: Binds to the muscarinic acetylcholine receptor (CHRM).
CC       {ECO:0000269|PubMed:8585087}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8585087}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=7489; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:8585087};
CC   -!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a proline
CC       residue stands at position 33 (Pro-31 in standard classification).
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC       subfamily. Aminergic toxin sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; Q9PSN1; -.
DR   SMR; Q9PSN1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   CDD; cd00206; snake_toxin; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR003571; Snake_3FTx.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR018354; Snake_toxin_con_site.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00272; SNAKE_TOXIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond;
KW   G-protein coupled acetylcholine receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..66
FT                   /note="Muscarinic toxin 4"
FT                   /evidence="ECO:0000269|PubMed:8585087"
FT                   /id="PRO_0000093643"
FT   DISULFID        3..24
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        17..42
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        46..58
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
FT   DISULFID        59..64
FT                   /evidence="ECO:0000250|UniProtKB:P60301"
SQ   SEQUENCE   66 AA;  7499 MW;  EAB0F54F4A00DD3E CRC64;
     LTCVTSKSIF GITTENCPDG QNLCFKKWYY IVPRYSDITW GCAATCPKPT NVRETIHCCE
     TDKCNE
 
 
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