HFQ_CAUVC
ID HFQ_CAUVC Reviewed; 82 AA.
AC Q9A7H8;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule:MF_00436};
GN Name=hfq {ECO:0000255|HAMAP-Rule:MF_00436}; OrderedLocusNames=CC_1745;
OS Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=190650;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19089 / CB15;
RX PubMed=11259647; DOI=10.1073/pnas.061029298;
RA Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT "Complete genome sequence of Caulobacter crescentus.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC -!- FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and
CC mRNAs to facilitate mRNA translational regulation in response to
CC envelope stress, environmental stress and changes in metabolite
CC concentrations. Also binds with high specificity to tRNAs.
CC {ECO:0000255|HAMAP-Rule:MF_00436}.
CC -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00436}.
CC -!- SIMILARITY: Belongs to the Hfq family. {ECO:0000255|HAMAP-
CC Rule:MF_00436}.
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DR EMBL; AE005673; AAK23721.1; -; Genomic_DNA.
DR PIR; E87465; E87465.
DR RefSeq; NP_420553.1; NC_002696.2.
DR RefSeq; WP_010919613.1; NC_002696.2.
DR PDB; 6GWK; X-ray; 2.15 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/U/V/W/X=1-82.
DR PDBsum; 6GWK; -.
DR AlphaFoldDB; Q9A7H8; -.
DR SMR; Q9A7H8; -.
DR STRING; 190650.CC_1745; -.
DR EnsemblBacteria; AAK23721; AAK23721; CC_1745.
DR KEGG; ccr:CC_1745; -.
DR PATRIC; fig|190650.5.peg.1769; -.
DR eggNOG; COG1923; Bacteria.
DR HOGENOM; CLU_113688_0_0_5; -.
DR OMA; QQMVYKH; -.
DR BioCyc; CAULO:CC1745-MON; -.
DR Proteomes; UP000001816; Chromosome.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd01716; Hfq; 1.
DR HAMAP; MF_00436; Hfq; 1.
DR InterPro; IPR005001; Hfq.
DR InterPro; IPR010920; LSM_dom_sf.
DR PANTHER; PTHR34772; PTHR34772; 1.
DR Pfam; PF17209; Hfq; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
DR TIGRFAMs; TIGR02383; Hfq; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; RNA-binding; Stress response.
FT CHAIN 1..82
FT /note="RNA-binding protein Hfq"
FT /id="PRO_0000095633"
FT HELIX 9..19
FT /evidence="ECO:0007829|PDB:6GWK"
FT STRAND 24..28
FT /evidence="ECO:0007829|PDB:6GWK"
FT STRAND 33..41
FT /evidence="ECO:0007829|PDB:6GWK"
FT STRAND 43..50
FT /evidence="ECO:0007829|PDB:6GWK"
FT STRAND 53..58
FT /evidence="ECO:0007829|PDB:6GWK"
FT HELIX 59..61
FT /evidence="ECO:0007829|PDB:6GWK"
FT STRAND 62..67
FT /evidence="ECO:0007829|PDB:6GWK"
SQ SEQUENCE 82 AA; 9242 MW; CCBFD5941D20C5DB CRC64;
MSAEKKQNLQ DTFLNSVRKS KTPLTIFLVN GVKLQGVVSW FDNFCVLLRR DGQSQLVYKH
AISTIMPAQP VQLYEPSADA DD
