ID   HFQ_LEPIN               Reviewed;          85 AA.
AC   Q8F5Z7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule:MF_00436};
GN   Name=hfq {ECO:0000255|HAMAP-Rule:MF_00436}; OrderedLocusNames=LA_1517;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS   56601).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=189518;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=56601;
RX   PubMed=12712204; DOI=10.1038/nature01597;
RA   Ren S.-X., Fu G., Jiang X.-G., Zeng R., Miao Y.-G., Xu H., Zhang Y.-X.,
RA   Xiong H., Lu G., Lu L.-F., Jiang H.-Q., Jia J., Tu Y.-F., Jiang J.-X.,
RA   Gu W.-Y., Zhang Y.-Q., Cai Z., Sheng H.-H., Yin H.-F., Zhang Y., Zhu G.-F.,
RA   Wan M., Huang H.-L., Qian Z., Wang S.-Y., Ma W., Yao Z.-J., Shen Y.,
RA   Qiang B.-Q., Xia Q.-C., Guo X.-K., Danchin A., Saint Girons I.,
RA   Somerville R.L., Wen Y.-M., Shi M.-H., Chen Z., Xu J.-G., Zhao G.-P.;
RT   "Unique physiological and pathogenic features of Leptospira interrogans
RT   revealed by whole-genome sequencing.";
RL   Nature 422:888-893(2003).
CC   -!- FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and
CC       mRNAs to facilitate mRNA translational regulation in response to
CC       envelope stress, environmental stress and changes in metabolite
CC       concentrations. Also binds with high specificity to tRNAs.
CC       {ECO:0000255|HAMAP-Rule:MF_00436}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00436}.
CC   -!- SIMILARITY: Belongs to the Hfq family. {ECO:0000255|HAMAP-
CC       Rule:MF_00436}.
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DR   EMBL; AE010300; AAN48716.1; -; Genomic_DNA.
DR   RefSeq; NP_711698.1; NC_004342.2.
DR   RefSeq; WP_001274793.1; NC_004342.2.
DR   AlphaFoldDB; Q8F5Z7; -.
DR   SMR; Q8F5Z7; -.
DR   STRING; 189518.LA_1517; -.
DR   EnsemblBacteria; AAN48716; AAN48716; LA_1517.
DR   GeneID; 61142131; -.
DR   KEGG; lil:LA_1517; -.
DR   PATRIC; fig|189518.3.peg.1516; -.
DR   HOGENOM; CLU_113688_0_2_12; -.
DR   InParanoid; Q8F5Z7; -.
DR   OMA; QQMVYKH; -.
DR   PRO; PR:Q8F5Z7; -.
DR   Proteomes; UP000001408; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0043487; P:regulation of RNA stability; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0045974; P:regulation of translation, ncRNA-mediated; IBA:GO_Central.
DR   CDD; cd01716; Hfq; 1.
DR   HAMAP; MF_00436; Hfq; 1.
DR   InterPro; IPR005001; Hfq.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   PANTHER; PTHR34772; PTHR34772; 1.
DR   Pfam; PF17209; Hfq; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   TIGRFAMs; TIGR02383; Hfq; 1.
PE   3: Inferred from homology;
KW   Reference proteome; RNA-binding; Stress response.
FT   CHAIN           1..85
FT                   /note="RNA-binding protein Hfq"
FT                   /id="PRO_0000095648"
SQ   SEQUENCE   85 AA;  9532 MW;  E99915C615042029 CRC64;
     MSAKNNIQDQ LLNTARKDKL DLTIYLLNGV PLKGKVVSFD NFTIVLEQEN KQSLVYKHAI
     STIIPAKIIK LYTEEAKDNK DAAQG