HFQ_PSEAE
ID HFQ_PSEAE Reviewed; 82 AA.
AC Q9HUM0;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule:MF_00436};
GN Name=hfq {ECO:0000255|HAMAP-Rule:MF_00436}; OrderedLocusNames=PA4944;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and
CC mRNAs to facilitate mRNA translational regulation in response to
CC envelope stress, environmental stress and changes in metabolite
CC concentrations. Also binds with high specificity to tRNAs.
CC {ECO:0000255|HAMAP-Rule:MF_00436}.
CC -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00436}.
CC -!- SIMILARITY: Belongs to the Hfq family. {ECO:0000255|HAMAP-
CC Rule:MF_00436}.
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DR EMBL; AE004091; AAG08329.1; -; Genomic_DNA.
DR PIR; D83028; D83028.
DR RefSeq; NP_253631.1; NC_002516.2.
DR RefSeq; WP_003095657.1; NZ_QZGE01000002.1.
DR PDB; 1U1S; X-ray; 1.60 A; A/B/C/D/E/F=1-82.
DR PDB; 1U1T; X-ray; 1.90 A; A/B/C/D/E/F=1-82.
DR PDB; 3INZ; X-ray; 1.70 A; A/B/C/D/E/F=1-82.
DR PDB; 3M4G; X-ray; 2.05 A; A/B/C/D/E/F/G/H/I/J/K/L=1-82.
DR PDB; 3QUI; X-ray; 1.93 A; A/B/C/D/E/F=1-82.
DR PDB; 4J5Y; X-ray; 2.10 A; A/B/C/D/E/F=1-82.
DR PDB; 4J6W; X-ray; 1.80 A; A/B/C/D/E/F=1-82.
DR PDB; 4J6X; X-ray; 2.22 A; A/B/C/D/E/F=1-82.
DR PDB; 4J6Y; X-ray; 2.14 A; A/B/C/D/E/F=1-82.
DR PDB; 4MMK; X-ray; 2.16 A; A/B/C/D/E/F/G/H/I/J/K/L=1-82.
DR PDB; 4MML; X-ray; 1.80 A; A=1-82.
DR PDB; 6O1K; EM; 3.13 A; C/D/E/F/G/H/I/J/K/L/M/N=5-71.
DR PDB; 6O1L; EM; 3.37 A; C/D/E/F/G/H/I/J/K/L/M/N=5-71.
DR PDB; 6O1M; EM; 3.15 A; C/D/E/F/G/H/I/J/K/L/M/N=5-71.
DR PDB; 6XYJ; X-ray; 2.77 A; AAA/BBB/CCC/DDD/EEE/FFF=1-82.
DR PDBsum; 1U1S; -.
DR PDBsum; 1U1T; -.
DR PDBsum; 3INZ; -.
DR PDBsum; 3M4G; -.
DR PDBsum; 3QUI; -.
DR PDBsum; 4J5Y; -.
DR PDBsum; 4J6W; -.
DR PDBsum; 4J6X; -.
DR PDBsum; 4J6Y; -.
DR PDBsum; 4MMK; -.
DR PDBsum; 4MML; -.
DR PDBsum; 6O1K; -.
DR PDBsum; 6O1L; -.
DR PDBsum; 6O1M; -.
DR PDBsum; 6XYJ; -.
DR AlphaFoldDB; Q9HUM0; -.
DR SMR; Q9HUM0; -.
DR STRING; 287.DR97_2297; -.
DR PaxDb; Q9HUM0; -.
DR PRIDE; Q9HUM0; -.
DR EnsemblBacteria; AAG08329; AAG08329; PA4944.
DR GeneID; 878015; -.
DR KEGG; pae:PA4944; -.
DR PATRIC; fig|208964.12.peg.5177; -.
DR PseudoCAP; PA4944; -.
DR HOGENOM; CLU_113688_2_2_6; -.
DR InParanoid; Q9HUM0; -.
DR OMA; QQMVYKH; -.
DR PhylomeDB; Q9HUM0; -.
DR BioCyc; PAER208964:G1FZ6-5060-MON; -.
DR EvolutionaryTrace; Q9HUM0; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0009372; P:quorum sensing; IMP:PseudoCAP.
DR GO; GO:0043609; P:regulation of carbon utilization; IDA:PseudoCAP.
DR GO; GO:0043487; P:regulation of RNA stability; IMP:PseudoCAP.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0006417; P:regulation of translation; IDA:PseudoCAP.
DR GO; GO:0045974; P:regulation of translation, ncRNA-mediated; IDA:PseudoCAP.
DR CDD; cd01716; Hfq; 1.
DR HAMAP; MF_00436; Hfq; 1.
DR InterPro; IPR005001; Hfq.
DR InterPro; IPR010920; LSM_dom_sf.
DR PANTHER; PTHR34772; PTHR34772; 1.
DR Pfam; PF17209; Hfq; 1.
DR SUPFAM; SSF50182; SSF50182; 1.
DR TIGRFAMs; TIGR02383; Hfq; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; RNA-binding; Stress response.
FT CHAIN 1..82
FT /note="RNA-binding protein Hfq"
FT /id="PRO_0000095656"
FT TURN 4..7
FT /evidence="ECO:0007829|PDB:3QUI"
FT HELIX 8..17
FT /evidence="ECO:0007829|PDB:1U1S"
FT STRAND 22..26
FT /evidence="ECO:0007829|PDB:1U1S"
FT STRAND 31..39
FT /evidence="ECO:0007829|PDB:1U1S"
FT STRAND 41..50
FT /evidence="ECO:0007829|PDB:1U1S"
FT STRAND 52..55
FT /evidence="ECO:0007829|PDB:1U1S"
FT HELIX 56..58
FT /evidence="ECO:0007829|PDB:1U1S"
FT STRAND 59..66
FT /evidence="ECO:0007829|PDB:1U1S"
SQ SEQUENCE 82 AA; 9104 MW; 1153661DC4C5AE2F CRC64;
MSKGHSLQDP YLNTLRKERV PVSIYLVNGI KLQGQIESFD QFVILLKNTV SQMVYKHAIS
TVVPSRPVRL PSGDQPAEPG NA
