ID   HFQ_YEREN               Reviewed;         101 AA.
AC   Q56928;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=RNA-binding protein Hfq {ECO:0000255|HAMAP-Rule:MF_00436};
DE   AltName: Full=Yersinia multiple regulator;
DE   AltName: Full=Yersinia regulator for pleiotropic phenotype;
GN   Name=hfq {ECO:0000255|HAMAP-Rule:MF_00436}; Synonyms=ymr, yrp;
OS   Yersinia enterocolitica.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=86-8;
RX   PubMed=8825090; DOI=10.1111/j.1365-2958.1995.18050859.x;
RA   Nakao H., Watanabe H., Nakayama S., Takeda T.;
RT   "yst gene expression in Yersinia enterocolitica is positively regulated by
RT   a chromosomal region that is highly homologous to Escherichia coli host
RT   factor 1 gene (hfq).";
RL   Mol. Microbiol. 18:859-865(1995).
CC   -!- FUNCTION: RNA chaperone that binds small regulatory RNA (sRNAs) and
CC       mRNAs to facilitate mRNA translational regulation in response to
CC       envelope stress, environmental stress and changes in metabolite
CC       concentrations. Also binds with high specificity to tRNAs (By
CC       similarity). Positively regulates the expression of the yst gene for
CC       heat-stable enterotoxin (Y-ST). {ECO:0000255|HAMAP-Rule:MF_00436}.
CC   -!- SUBUNIT: Homohexamer. {ECO:0000255|HAMAP-Rule:MF_00436}.
CC   -!- SIMILARITY: Belongs to the Hfq family. {ECO:0000255|HAMAP-
CC       Rule:MF_00436}.
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DR   EMBL; D28762; BAA05952.1; -; Genomic_DNA.
DR   PIR; S70842; S70842.
DR   RefSeq; WP_004392473.1; NZ_UHIX01000001.1.
DR   AlphaFoldDB; Q56928; -.
DR   SMR; Q56928; -.
DR   STRING; 1443113.LC20_04803; -.
DR   GeneID; 61905531; -.
DR   GeneID; 67419304; -.
DR   eggNOG; COG1923; Bacteria.
DR   OMA; QQMVYKH; -.
DR   OrthoDB; 1989988at2; -.
DR   PHI-base; PHI:6403; -.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd01716; Hfq; 1.
DR   HAMAP; MF_00436; Hfq; 1.
DR   InterPro; IPR005001; Hfq.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   PANTHER; PTHR34772; PTHR34772; 1.
DR   Pfam; PF17209; Hfq; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   TIGRFAMs; TIGR02383; Hfq; 1.
PE   3: Inferred from homology;
KW   RNA-binding; Stress response.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..101
FT                   /note="RNA-binding protein Hfq"
FT                   /id="PRO_0000095608"
FT   REGION          63..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..101
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   101 AA;  11143 MW;  767D3C06B221441D CRC64;
     MAKGQSLQDP FLNALRRERV PVSIYLVNGI KLQGQVESFD QFVILLKNTV SQMVYKHAIS
     TVVPSRPVSH HSNNPSGSTN NYHGSNPSAP QQPQQDSDDA E