ID   HFW1_DROPS              Reviewed;         595 AA.
AC   P84329; Q29J19;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Protein halfway;
DE   AltName: Full=Protein singed wings;
GN   Name=hfw; ORFNames=GA15922;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000305}
RP   IDENTIFICATION.
RX   PubMed=15189568; DOI=10.1186/1471-2156-5-15;
RA   Schwartz Y.B., Boykova T., Belyaeva E.S., Ashburner M., Zhimulev I.F.;
RT   "Molecular characterization of the singed wings locus of Drosophila
RT   melanogaster.";
RL   BMC Genet. 5:15-15(2004).
CC   -!- FUNCTION: Has a role in the ecdysone induced cascade; probably indirect
CC       control of 'late' ecdysone genes. {ECO:0000250|UniProtKB:Q9W568}.
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DR   EMBL; CH379063; EAL32483.2; -; Genomic_DNA.
DR   AlphaFoldDB; P84329; -.
DR   SMR; P84329; -.
DR   STRING; 7237.FBpp0272920; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   HOGENOM; CLU_028059_2_0_1; -.
DR   InParanoid; P84329; -.
DR   OMA; RLQCDCN; -.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0035556; P:intracellular signal transduction; ISS:UniProtKB.
DR   GO; GO:0035073; P:pupariation; ISS:UniProtKB.
DR   GO; GO:0035075; P:response to ecdysone; ISS:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   Pfam; PF13855; LRR_8; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   3: Inferred from homology;
KW   Glycoprotein; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..595
FT                   /note="Protein halfway"
FT                   /id="PRO_0000083962"
FT   DOMAIN          347..402
FT                   /note="LRRNT"
FT   REPEAT          403..424
FT                   /note="LRR 1"
FT   REPEAT          429..450
FT                   /note="LRR 2"
FT   REPEAT          454..475
FT                   /note="LRR 3"
FT   DOMAIN          489..538
FT                   /note="LRRCT"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        250
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        255
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   595 AA;  66567 MW;  55A798752266C7A9 CRC64;
     MLLTTGHARA RPEQQQASAD EPLEAKPEDG HSLTAPRPAD DELATVAPTT TPVPAVAITQ
     GATTGAATEA THSQPVVTAV PATSSTSTST TVPAPLLPAA PEQPEYLKHC FYADEHLCMY
     GHDGQGNEAP DVLGHISTTP ESDSQGIGLQ VNASQGNSQN LERNANSCQC HEHPAKANSW
     YCCNISQMSM ISSCSNISKW TNLHVRNLTV RTIDLSNPIF RSLQSLAVTD GNITRLINAF
     PRHSALKCLN ISNNNISEIP SRMFKDVPHL EFFGMSRNNL SLVPHHNQNK NITVDISGNM
     RMLCNPLNEI INNDSFNFVN PKHSYCLYNA THEWFQSTDL VSVEQLESTK RCMTKCPVIP
     NYGSCKCRFE SIMIIQDDQS KPKCHVDCSN LGLVELPPRL PDNTFVLNIT NNKITSLGDH
     FQTNPTYHNI NRLVADNNQI SSIYEFEGTK FIENFQRIYM RNNSLSKIPE YFLNNALMDT
     GRRIYLAGNK LQCDCNSAKT LQNWLKERST DIPDYMEIRC RNIPQSVIEL QEAKLCQSPP
     DWTDYIYYLI AAEVILLLGL ITKVSYDYWV FKTSGYLPWP ASKMPKLPCD WLCES