HFW2_DROME
ID HFW2_DROME Reviewed; 499 AA.
AC Q8SXT3; Q9V863;
DT 07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Protein singed wings 2;
DE Flags: Precursor;
GN Name=swi2 {ECO:0000312|FlyBase:FBgn0034262}; ORFNames=CG14485;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF57813.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF57813.3}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL89887.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL89887.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=15189568; DOI=10.1186/1471-2156-5-15;
RA Schwartz Y.B., Boykova T., Belyaeva E.S., Ashburner M., Zhimulev I.F.;
RT "Molecular characterization of the singed wings locus of Drosophila
RT melanogaster.";
RL BMC Genet. 5:15-15(2004).
CC -!- FUNCTION: Has a role in the ecdysone induced cascade; probably indirect
CC control of 'late' ecdysone genes. {ECO:0000250|UniProtKB:Q9W568}.
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DR EMBL; AE013599; AAF57813.3; -; Genomic_DNA.
DR EMBL; AY084149; AAL89887.1; -; mRNA.
DR RefSeq; NP_611247.3; NM_137403.4.
DR AlphaFoldDB; Q8SXT3; -.
DR SMR; Q8SXT3; -.
DR BioGRID; 62696; 1.
DR STRING; 7227.FBpp0086049; -.
DR PaxDb; Q8SXT3; -.
DR DNASU; 37010; -.
DR EnsemblMetazoa; FBtr0086889; FBpp0086049; FBgn0034262.
DR GeneID; 37010; -.
DR KEGG; dme:Dmel_CG14485; -.
DR UCSC; CG14485-RA; d. melanogaster.
DR CTD; 37010; -.
DR FlyBase; FBgn0034262; swi2.
DR VEuPathDB; VectorBase:FBgn0034262; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_028059_0_0_1; -.
DR InParanoid; Q8SXT3; -.
DR OMA; RNPWHCT; -.
DR OrthoDB; 485946at2759; -.
DR PhylomeDB; Q8SXT3; -.
DR Reactome; R-DME-114608; Platelet degranulation.
DR BioGRID-ORCS; 37010; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37010; -.
DR PRO; PR:Q8SXT3; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034262; Expressed in adult hindgut (Drosophila) and 16 other tissues.
DR ExpressionAtlas; Q8SXT3; baseline and differential.
DR Genevisible; Q8SXT3; DM.
DR GO; GO:0035556; P:intracellular signal transduction; ISS:UniProtKB.
DR GO; GO:0035073; P:pupariation; ISS:UniProtKB.
DR GO; GO:0035075; P:response to ecdysone; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR032675; LRR_dom_sf.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat; Reference proteome; Repeat; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..499
FT /note="Protein singed wings 2"
FT /id="PRO_0000021414"
FT REPEAT 154..175
FT /note="LRR 1"
FT REPEAT 178..199
FT /note="LRR 2"
FT DOMAIN 210..265
FT /note="LRRCT 1"
FT REPEAT 307..328
FT /note="LRR 3"
FT REPEAT 332..353
FT /note="LRR 4"
FT REPEAT 357..378
FT /note="LRR 5"
FT DOMAIN 394..449
FT /note="LRRCT 2"
SQ SEQUENCE 499 AA; 58032 MW; 4905E62D2433599C CRC64;
MPSGVFQKRP KAAETISLFC MILIRLSRAA DDSHETSTLL ATITTITTEI IPMPDSGRSC
FGWSSAPEAA GGNCSRSNRN GTLKCYGGMN NLAALNQSGK LSRVQPALEM LLCGWPKDGL
NHFRDLQKLP RLRSLTIEYS GFTEFKFDFP EMLELHTINI SWTNLSYISS RTFKRVHPLK
VLDLRWNQLI QLDGPLLLPR NFEQLYLAGN PWNCTRNFKW LLLQPEKGRL VVDRDELICT
DRKYKERQML MVMHYKLELK RQCQSHEDLR NCTCLMHHIL PKTHIPLYTV NCSHLQFHRL
PDFLPDNTTT LVINDNMISD INPLRDNPHY RHVVDMQLEN NQISNVDNLE DTYWLQNFRL
LNLRGNNLRK LHVYALDNAL DDNENANLLL LSRNPWHCTC KFGSRMRELL TKYKDIVRDA
WNVSCTYRLD DDQLLAKVLT LSRQEMCNLS VEGGTQIHPI DWLNGVLASL IFLILGKLAY
DYYYYKYYGR VPWIVMKMP
