ID   HGBC_HAEIF              Reviewed;         993 AA.
AC   Q9KIV0;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Hemoglobin-binding protein C;
DE   Flags: Precursor;
GN   Name=hgbC;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NTHi N182;
RX   PubMed=10858226; DOI=10.1128/iai.68.7.4092-4101.2000;
RA   Cope L.D., Hrkal Z., Hansen E.J.;
RT   "Detection of phase variation in expression of proteins involved in
RT   hemoglobin and hemoglobin-haptoglobin binding by nontypeable Haemophilus
RT   influenzae.";
RL   Infect. Immun. 68:4092-4101(2000).
CC   -!- FUNCTION: Acts as a receptor for hemoglobin of the human host and is
CC       required for heme uptake.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- MISCELLANEOUS: This protein is subject to phase-variable expression
CC       associated with alteration in the length of the CCAA repeat region.
CC       This mechanism is called slipped-strand mispairing. Addition or loss of
CC       CCAA repeat units would change the reading frame and result in
CC       introduction of stop codons downstream of the repeat region. This may
CC       be a mechanism of regulation and a way to avoid the immunological
CC       response of the host.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
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DR   EMBL; AF221060; AAF80178.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9KIV0; -.
DR   SMR; Q9KIV0; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProt.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Repeat; Signal; TonB box;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..993
FT                   /note="Hemoglobin-binding protein C"
FT                   /id="PRO_0000034783"
FT   REPEAT          26..29
FT                   /note="1"
FT   REPEAT          30..33
FT                   /note="2"
FT   REPEAT          34..37
FT                   /note="3"
FT   REGION          26..37
FT                   /note="3 X 4 AA tandem repeats of Q-P-T-N"
FT   MOTIF           47..54
FT                   /note="TonB box"
FT   MOTIF           976..993
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   993 AA;  113617 MW;  A551BF3B2C641612 CRC64;
     MANFRLNVLA YSVMLGLTAG VAYAAQPTNQ PTNQPTNQNS NVSEQLEQIN VSGSTENSDT
     KTPPKIAETV KTAKTLEREQ ANNIKDIVKY ETGVTVVEAG RFGQSGFAIR GVDENRVAIN
     IDGLRQAETL SSQGFKELFE GYGNFNNTRN GAEIETLKEV NITKGANSIK SGSGSLGGSV
     IYKTKDARDY LLNKDYYVSY KKGYATENNQ SFNTLTLAGR YKKFDALVVT TRRNGHELEN
     YDYKNADSLT QGKKREKADP YKIEQDSTLL KLSFNPTENH RFTLAADLYE HRSRGQDLSY
     TLKYQRSGNE TPEVESRHTN DKTKRRNISF SYENFSQTPF WDTLKLTYSD QRIKTRARTD
     EYCDAGVTHC QGTENPTGLK LTNGKITRRN GTDLQFKEKG TAADGTKTYD FDTFIDTNNQ
     EIVGKLNLGY ANDTWYDCSL FDCKDGTKMK VFEGNATYGY IGKWRESELE TEVLNGRKFA
     RIKDRKDKNN RDNRKIKSIL PSSPGYLERL WQERDLDTNT QQLNLDLTKD FKTWRVEHNL
     QYGSSYNTTM KRMVNRAGYD ATDVQWWAKR TLGKSHNFFT GQDIVETCAT TSSSAWNAFL
     CPRVDPEFSY LLPIKTKEKS VYLFDNVVIT DYLSFDLGYR YDNIHYQPKY KHGVTPKLPD
     DIVKGLFIPL PDKPNSNQVK ENVQQNIDYI AKQNKKYKAH SYSFASTIDP TSFLRLQLKY
     SKGFRAPTSD EMYFTFKHPD FTILPNTNLK PEIAKTKEIA FTLHNDDWGF ISTSLFKTNY
     RDFIDLVHKG TRKFKVGKPG SEGEIEFDTF QNINRDSAVV KGIEINSKVF LGKMAKFMDG
     FNLSYKYTYQ KGRMDGNIPM NAIQPKTMVY GLGYDHPSQK FGFNFYTTHV ASKNPEDTYD
     IYAKDKNQTD TSIKWRSKSY TILDLIGYVQ PIKNLTIRAG VYNLTNRKYI TWDSARSIRS
     FGTSNVIDQS TGQGINRFYA PGRNYKMSVQ FEF