HGC1_CANAL
ID HGC1_CANAL Reviewed; 785 AA.
AC Q5ABE2; A0A1D8PCA7;
DT 13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2017, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Hypha-specific G1 cyclin-related protein 1;
GN Name=HGC1; Synonyms=CLN21, CLN3; OrderedLocusNames=CAALFM_C100780CA;
GN ORFNames=CaO19.13449, CaO19.6028;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, INDUCTION, AND INTERACTION WITH CDC28.
RX PubMed=15071502; DOI=10.1038/sj.emboj.7600195;
RA Zheng X., Wang Y., Wang Y.;
RT "Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida
RT albicans hyphal morphogenesis.";
RL EMBO J. 23:1845-1856(2004).
RN [5]
RP INDUCTION.
RX PubMed=15643064; DOI=10.1128/ec.4.1.90-94.2005;
RA Chapa y Lazo B., Bates S., Sudbery P.;
RT "The G1 cyclin Cln3 regulates morphogenesis in Candida albicans.";
RL Eukaryot. Cell 4:90-94(2005).
RN [6]
RP INDUCTION.
RX PubMed=15755921; DOI=10.1128/ec.4.3.588-603.2005;
RA Bassilana M., Hopkins J., Arkowitz R.A.;
RT "Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal
RT growth.";
RL Eukaryot. Cell 4:588-603(2005).
RN [7]
RP INDUCTION.
RX PubMed=16002646; DOI=10.1128/ec.4.7.1203-1210.2005;
RA Enjalbert B., Whiteway M.;
RT "Release from quorum-sensing molecules triggers hyphal formation during
RT Candida albicans resumption of growth.";
RL Eukaryot. Cell 4:1203-1210(2005).
RN [8]
RP INDUCTION.
RX PubMed=16000712; DOI=10.1099/mic.0.27999-0;
RA Hanaoka N., Umeyama T., Ueno K., Ueda K., Beppu T., Fugo H., Uehara Y.,
RA Niimi M.;
RT "A putative dual-specific protein phosphatase encoded by YVH1 controls
RT growth, filamentation and virulence in Candida albicans.";
RL Microbiology 151:2223-2232(2005).
RN [9]
RP FUNCTION, AND INDUCTION.
RX PubMed=16998076; DOI=10.1128/ec.00151-06;
RA Kaneko A., Umeyama T., Utena-Abe Y., Yamagoe S., Niimi M., Uehara Y.;
RT "Tcc1p, a novel protein containing the tetratricopeptide repeat motif,
RT interacts with Tup1p to regulate morphological transition and virulence in
RT Candida albicans.";
RL Eukaryot. Cell 5:1894-1905(2006).
RN [10]
RP INDUCTION.
RX PubMed=16267276; DOI=10.1091/mbc.e05-06-0502;
RA Cao F., Lane S., Raniga P.P., Lu Y., Zhou Z., Ramon K., Chen J., Liu H.;
RT "The Flo8 transcription factor is essential for hyphal development and
RT virulence in Candida albicans.";
RL Mol. Biol. Cell 17:295-307(2006).
RN [11]
RP FUNCTION, AND INDUCTION.
RX PubMed=16468988; DOI=10.1111/j.1365-2958.2005.05038.x;
RA Andaluz E., Ciudad T., Gomez-Raja J., Calderone R., Larriba G.;
RT "Rad52 depletion in Candida albicans triggers both the DNA-damage
RT checkpoint and filamentation accompanied by but independent of expression
RT of hypha-specific genes.";
RL Mol. Microbiol. 59:1452-1472(2006).
RN [12]
RP INTERACTION WITH CDC28, AND FUNCTION.
RX PubMed=17765684; DOI=10.1016/j.devcel.2007.06.011;
RA Sinha I., Wang Y.M., Philp R., Li C.R., Yap W.H., Wang Y.;
RT "Cyclin-dependent kinases control septin phosphorylation in Candida
RT albicans hyphal development.";
RL Dev. Cell 13:421-432(2007).
RN [13]
RP FUNCTION.
RX PubMed=17673907; DOI=10.1038/sj.emboj.7601814;
RA Zheng X.D., Lee R.T., Wang Y.M., Lin Q.S., Wang Y.;
RT "Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida
RT albicans hyphal growth.";
RL EMBO J. 26:3760-3769(2007).
RN [14]
RP INDUCTION.
RX PubMed=17172437; DOI=10.1128/ec.00380-06;
RA Wang A., Lane S., Tian Z., Sharon A., Hazan I., Liu H.;
RT "Temporal and spatial control of HGC1 expression results in Hgc1
RT localization to the apical cells of hyphae in Candida albicans.";
RL Eukaryot. Cell 6:253-261(2007).
RN [15]
RP FUNCTION.
RX PubMed=18234840; DOI=10.1091/mbc.e07-09-0876;
RA Gonzalez-Novo A., Correa-Bordes J., Labrador L., Sanchez M.,
RA Vazquez de Aldana C.R., Jimenez J.;
RT "Sep7 is essential to modify septin ring dynamics and inhibit cell
RT separation during Candida albicans hyphal growth.";
RL Mol. Biol. Cell 19:1509-1518(2008).
RN [16]
RP INDUCTION.
RX PubMed=19054126; DOI=10.1111/j.1567-1364.2008.00459.x;
RA Zeidler U., Lettner T., Lassnig C., Muller M., Lajko R., Hintner H.,
RA Breitenbach M., Bito A.;
RT "UME6 is a crucial downstream target of other transcriptional regulators of
RT true hyphal development in Candida albicans.";
RL FEMS Yeast Res. 9:126-142(2009).
RN [17]
RP FUNCTION.
RX PubMed=19528234; DOI=10.1128/mcb.01502-08;
RA Wang A., Raniga P.P., Lane S., Lu Y., Liu H.;
RT "Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of
RT Efg1 represses cell separation genes.";
RL Mol. Cell. Biol. 29:4406-4416(2009).
RN [18]
RP FUNCTION.
RX PubMed=20639857; DOI=10.1038/emboj.2010.158;
RA Bishop A., Lane R., Beniston R., Chapa-y-Lazo B., Smythe C., Sudbery P.;
RT "Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by
RT the Cdc28-Ccn1/Hgc1 kinase.";
RL EMBO J. 29:2930-2942(2010).
RN [19]
RP FUNCTION.
RX PubMed=20023069; DOI=10.1128/ec.00307-09;
RA Wilson D., Hube B.;
RT "Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during
RT circulation.";
RL Eukaryot. Cell 9:278-287(2010).
RN [20]
RP FUNCTION, AND INDUCTION.
RX PubMed=20656912; DOI=10.1128/ec.00046-10;
RA Carlisle P.L., Kadosh D.;
RT "Candida albicans Ume6, a filament-specific transcriptional regulator,
RT directs hyphal growth via a pathway involving Hgc1 cyclin-related
RT protein.";
RL Eukaryot. Cell 9:1320-1328(2010).
RN [21]
RP FUNCTION.
RX PubMed=21407800; DOI=10.1371/journal.pone.0017046;
RA Wachtler B., Wilson D., Haedicke K., Dalle F., Hube B.;
RT "From attachment to damage: defined genes of Candida albicans mediate
RT adhesion, invasion and damage during interaction with oral epithelial
RT cells.";
RL PLoS ONE 6:E17046-E17046(2011).
RN [22]
RP FUNCTION.
RX PubMed=23223035; DOI=10.1128/ec.00163-12;
RA Banerjee M., Uppuluri P., Zhao X.R., Carlisle P.L., Vipulanandan G.,
RA Villar C.C., Lopez-Ribot J.L., Kadosh D.;
RT "Expression of UME6, a key regulator of Candida albicans hyphal
RT development, enhances biofilm formation via Hgc1- and Sun41-dependent
RT mechanisms.";
RL Eukaryot. Cell 12:224-232(2013).
RN [23]
RP INDUCTION.
RX PubMed=23210679; DOI=10.3109/13693786.2012.743051;
RA Hsu C.C., Lai W.L., Chuang K.C., Lee M.H., Tsai Y.C.;
RT "The inhibitory activity of linalool against the filamentous growth and
RT biofilm formation in Candida albicans.";
RL Med. Mycol. 51:473-482(2013).
RN [24]
RP INDUCTION.
RX PubMed=23242994; DOI=10.1091/mbc.e12-01-0065;
RA Carlisle P.L., Kadosh D.;
RT "A genome-wide transcriptional analysis of morphology determination in
RT Candida albicans.";
RL Mol. Biol. Cell 24:246-260(2013).
RN [25]
RP FUNCTION.
RX PubMed=23808664; DOI=10.1111/mmi.12310;
RA Guan G., Xie J., Tao L., Nobile C.J., Sun Y., Cao C., Tong Y., Huang G.;
RT "Bcr1 plays a central role in the regulation of opaque cell filamentation
RT in Candida albicans.";
RL Mol. Microbiol. 89:732-750(2013).
RN [26]
RP FUNCTION.
RX PubMed=23505370; DOI=10.1371/journal.ppat.1003210;
RA Si H., Hernday A.D., Hirakawa M.P., Johnson A.D., Bennett R.J.;
RT "Candida albicans white and opaque cells undergo distinct programs of
RT filamentous growth.";
RL PLoS Pathog. 9:E1003210-E1003210(2013).
RN [27]
RP FUNCTION.
RX PubMed=23637598; DOI=10.1371/journal.ppat.1003305;
RA Lin C.H., Kabrawala S., Fox E.P., Nobile C.J., Johnson A.D., Bennett R.J.;
RT "Genetic control of conventional and pheromone-stimulated biofilm formation
RT in Candida albicans.";
RL PLoS Pathog. 9:E1003305-E1003305(2013).
CC -!- FUNCTION: Hypha-specific G1 cyclin-related protein involved in
CC regulation of morphogenesis and opaque cells filamentous growth, and
CC required for both conventional and pheromone-stimulated biofilm
CC formation. Required to maintain hyphal tip localization of actin and
CC SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1
CC complex phosphorylates and prevents RGA2 from localizing to hyphal
CC tips, leading to localized CDC42 activation for hyphal extension. The
CC CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11
CC phosphorylation throughout hyphal growth. Moreover CDC28-HGC1
CC phosphorylation of EFG1 represses cell separation genes during hyphal
CC growth. Also partially controls SEP7 phosphorylation status and
CC subsequent septin ring dynamics. Required for virulence and especially
CC mediates dynamic adhesion to endothelium of blood vessels during
CC circulation. {ECO:0000269|PubMed:15071502, ECO:0000269|PubMed:16468988,
CC ECO:0000269|PubMed:16998076, ECO:0000269|PubMed:17673907,
CC ECO:0000269|PubMed:17765684, ECO:0000269|PubMed:18234840,
CC ECO:0000269|PubMed:19528234, ECO:0000269|PubMed:20023069,
CC ECO:0000269|PubMed:20639857, ECO:0000269|PubMed:20656912,
CC ECO:0000269|PubMed:21407800, ECO:0000269|PubMed:23223035,
CC ECO:0000269|PubMed:23505370, ECO:0000269|PubMed:23637598,
CC ECO:0000269|PubMed:23808664}.
CC -!- SUBUNIT: Interacts with CDC28. {ECO:0000269|PubMed:15071502,
CC ECO:0000269|PubMed:17765684}.
CC -!- INDUCTION: Transcript is detected only in the apical cells of hyphae,
CC suggesting that HGC1 is transcribed in the apical cell. Induced during
CC hyphal formation and upon exposure to host serum. Expression is
CC regulated by the cAMP/PKA pathway, EFG1, FLO8, SSN6, RAD52, TUP1, and
CC UME6. Repressed by farnesol and linalool. {ECO:0000269|PubMed:15071502,
CC ECO:0000269|PubMed:15643064, ECO:0000269|PubMed:15755921,
CC ECO:0000269|PubMed:16000712, ECO:0000269|PubMed:16002646,
CC ECO:0000269|PubMed:16267276, ECO:0000269|PubMed:16468988,
CC ECO:0000269|PubMed:16998076, ECO:0000269|PubMed:17172437,
CC ECO:0000269|PubMed:19054126, ECO:0000269|PubMed:20656912,
CC ECO:0000269|PubMed:23210679, ECO:0000269|PubMed:23242994}.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR EMBL; CP017623; AOW25775.1; -; Genomic_DNA.
DR RefSeq; XP_718990.2; XM_713897.2.
DR AlphaFoldDB; Q5ABE2; -.
DR SMR; Q5ABE2; -.
DR BioGRID; 1222443; 4.
DR IntAct; Q5ABE2; 2.
DR MINT; Q5ABE2; -.
DR STRING; 237561.Q5ABE2; -.
DR PRIDE; Q5ABE2; -.
DR GeneID; 3639349; -.
DR KEGG; cal:CAALFM_C100780CA; -.
DR CGD; CAL0000184055; HGC1.
DR VEuPathDB; FungiDB:C1_00780C_A; -.
DR eggNOG; KOG0653; Eukaryota.
DR HOGENOM; CLU_019984_0_0_1; -.
DR InParanoid; Q5ABE2; -.
DR OrthoDB; 993640at2759; -.
DR PHI-base; PHI:3506; -.
DR PHI-base; PHI:357; -.
DR PRO; PR:Q5ABE2; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR028857; CCNF_metazoan.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF252; PTHR10177:SF252; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Reference proteome; Virulence.
FT CHAIN 1..785
FT /note="Hypha-specific G1 cyclin-related protein 1"
FT /id="PRO_0000424340"
FT DOMAIN 71..238
FT /note="Cyclin N-terminal"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..679
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 87674 MW; 337429A85FA1CB8C CRC64;
MINITKPLTP KSISQQKQQQ QHPYKNISTT KSNNNPQASG SKSFVQEKYP SQLYESEIKI
HNQSLAEYDL DIYDIMVNLI ETNKPNLSLY KQQPYLTFTI RLKLIDFLLK MSIRLKILPF
VFFKAVKIFD RYCSKRIVLL DQSQLIITTC LWIASKVMGG NNHFVNINNL DKIGHENFRT
INDLGYGCGG KYLGPTERFR LPKLHELVKL CGAKCKYDQG MFKQMEVHVL NTLEWSLNDP
SIEEFIIDSH EFNVININNN NEYEQTITTN DESANANAND GNEFFKIKEF LSYAALYSHD
LIDTNIIELG QVIMDLINET FQLQPFDKHY QTILNCDSDH PIRFDMQRYK HIKKAVIKSV
LNASDFMMKV FHSKGPQFIY QQFNLQYKLN YTTNSIIGGF GNSGYSPTTT TTTTTSDNIS
TTPTSSTGST TPVSSYIGYA NSRSSSVSST SSVASSSNAN TPSSSCSTTS TTPLGMTPHK
RQKNYSNYSN YSNYSNSSTS LGLTNNNNNN TTISPVDSTT INSHTKNSSQ LNYQYHNGGS
NNNNHHHHHK PSLSVSIPPP QMHSHHHSST VYQMVTPPNS ANKNSNKSNS ANNNNTTTIA
TTTTTTTNNN NNSQLPAPHQ LSYNNYFNSP NMQPPPPMKY TPGRKQQQQQ NQGQNQQQPL
QLYQGDNNNN GTNTNSKFNS IAGSRAVSSS SSSAVSIASS ISTNNYDKYD DDDDDDNSND
LFSSSRRFMN YSNYSSSTIN GSVMSGVINN NSGNGKGNGN GGSGTPISEN DSPIYTKTRL
CNMIH
