ID   HGH1_DROME              Reviewed;         369 AA.
AC   Q9VBG6; Q95S85;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Protein HGH1 homolog;
GN   ORFNames=CG6073;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo, and Ovary;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- SIMILARITY: Belongs to the HGH1 family. {ECO:0000305}.
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DR   EMBL; AE014297; AAF56576.2; -; Genomic_DNA.
DR   EMBL; AY060916; AAL28464.1; -; mRNA.
DR   EMBL; AY128461; AAM75054.1; -; mRNA.
DR   RefSeq; NP_001247313.1; NM_001260384.2.
DR   RefSeq; NP_651468.1; NM_143211.4.
DR   AlphaFoldDB; Q9VBG6; -.
DR   SMR; Q9VBG6; -.
DR   BioGRID; 68077; 2.
DR   STRING; 7227.FBpp0084375; -.
DR   PaxDb; Q9VBG6; -.
DR   PRIDE; Q9VBG6; -.
DR   EnsemblMetazoa; FBtr0085003; FBpp0084375; FBgn0039417.
DR   EnsemblMetazoa; FBtr0307342; FBpp0298343; FBgn0039417.
DR   GeneID; 43180; -.
DR   KEGG; dme:Dmel_CG6073; -.
DR   UCSC; CG6073-RA; d. melanogaster.
DR   FlyBase; FBgn0039417; CG6073.
DR   VEuPathDB; VectorBase:FBgn0039417; -.
DR   eggNOG; KOG2973; Eukaryota.
DR   GeneTree; ENSGT00390000016546; -.
DR   HOGENOM; CLU_037769_3_0_1; -.
DR   InParanoid; Q9VBG6; -.
DR   OMA; HRWEKDV; -.
DR   OrthoDB; 1094436at2759; -.
DR   PhylomeDB; Q9VBG6; -.
DR   BioGRID-ORCS; 43180; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 43180; -.
DR   PRO; PR:Q9VBG6; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0039417; Expressed in ovary and 27 other tissues.
DR   ExpressionAtlas; Q9VBG6; baseline and differential.
DR   Genevisible; Q9VBG6; DM.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039717; Hgh1.
DR   InterPro; IPR007206; Protein_HGH1_C.
DR   InterPro; IPR007205; Protein_HGH1_N.
DR   PANTHER; PTHR13387; PTHR13387; 1.
DR   Pfam; PF04063; DUF383; 1.
DR   Pfam; PF04064; DUF384; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..369
FT                   /note="Protein HGH1 homolog"
FT                   /id="PRO_0000331583"
SQ   SEQUENCE   369 AA;  41799 MW;  ADDC53E9D752DA84 CRC64;
     METVKELVQF MQPNQRLDLK AVALTHVLGL TGSSEGKSAI LSLDEMLMAI FGLTFDANQT
     VAKDAVLSLI NLTSEEEAAI KVFQLAKQLQ PPFAIVEVAA KEITNEQSDL ADPWSMVLSN
     LTRVESLVHE ILDTLERDDH TLPRLAKAFA QLDYNKKKAK LHYLAPIFCN LTQVSRGREL
     CCHRKYELLE KLLPFASFEG SVVRRGGTIG ILKNVCFDTV YHDVILNEQS SILVAILQPL
     CGPEEFSDED NELLPIELQY LPESKTREED PDLRKMLLEC LLQLCSTRRS REILRSRGVY
     EILREYHKWE AKVGKDSDCL LACENVVDIL IKKEEEIGLD NYKTEVEVPA EQSEKFVQED
     AAYVKSLLD