HGH1_HUMAN
ID HGH1_HUMAN Reviewed; 390 AA.
AC Q9BTY7; P0CB43;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Protein HGH1 homolog;
GN Name=HGH1; Synonyms=C8orf30A, C8orf30B, FAM203A, FAM203B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-24 AND 56-79, CLEAVAGE OF INITIATOR METHIONINE,
RP ACETYLATION AT GLY-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V.;
RL Submitted (JAN-2010) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-388, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-214, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SIMILARITY: Belongs to the HGH1 family. {ECO:0000305}.
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DR EMBL; AC104592; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003035; AAH03035.1; -; mRNA.
DR EMBL; BC009915; AAH09915.1; -; mRNA.
DR CCDS; CCDS6417.1; -.
DR RefSeq; NP_057542.2; NM_016458.3.
DR AlphaFoldDB; Q9BTY7; -.
DR SMR; Q9BTY7; -.
DR BioGRID; 119398; 62.
DR IntAct; Q9BTY7; 13.
DR MINT; Q9BTY7; -.
DR STRING; 9606.ENSP00000321320; -.
DR GlyGen; Q9BTY7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BTY7; -.
DR PhosphoSitePlus; Q9BTY7; -.
DR BioMuta; HGH1; -.
DR DMDM; 74733161; -.
DR EPD; Q9BTY7; -.
DR jPOST; Q9BTY7; -.
DR MassIVE; Q9BTY7; -.
DR MaxQB; Q9BTY7; -.
DR PaxDb; Q9BTY7; -.
DR PeptideAtlas; Q9BTY7; -.
DR PRIDE; Q9BTY7; -.
DR Antibodypedia; 28319; 159 antibodies from 27 providers.
DR DNASU; 51236; -.
DR Ensembl; ENST00000347708.5; ENSP00000321320.5; ENSG00000235173.7.
DR GeneID; 51236; -.
DR KEGG; hsa:51236; -.
DR MANE-Select; ENST00000347708.5; ENSP00000321320.5; NM_016458.4; NP_057542.2.
DR UCSC; uc010mfs.4; human.
DR CTD; 51236; -.
DR DisGeNET; 51236; -.
DR GeneCards; HGH1; -.
DR HGNC; HGNC:24161; HGH1.
DR HPA; ENSG00000235173; Low tissue specificity.
DR neXtProt; NX_Q9BTY7; -.
DR OpenTargets; ENSG00000235173; -.
DR PharmGKB; PA142672348; -.
DR VEuPathDB; HostDB:ENSG00000235173; -.
DR eggNOG; KOG2973; Eukaryota.
DR GeneTree; ENSGT00390000016546; -.
DR HOGENOM; CLU_037769_3_0_1; -.
DR InParanoid; Q9BTY7; -.
DR OMA; HRWEKDV; -.
DR OrthoDB; 1094436at2759; -.
DR PhylomeDB; Q9BTY7; -.
DR TreeFam; TF313296; -.
DR PathwayCommons; Q9BTY7; -.
DR SignaLink; Q9BTY7; -.
DR BioGRID-ORCS; 51236; 11 hits in 1001 CRISPR screens.
DR ChiTaRS; HGH1; human.
DR GenomeRNAi; 51236; -.
DR Pharos; Q9BTY7; Tdark.
DR PRO; PR:Q9BTY7; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9BTY7; protein.
DR Bgee; ENSG00000235173; Expressed in ileal mucosa and 181 other tissues.
DR ExpressionAtlas; Q9BTY7; baseline and differential.
DR Genevisible; Q9BTY7; HS.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039717; Hgh1.
DR InterPro; IPR007206; Protein_HGH1_C.
DR InterPro; IPR007205; Protein_HGH1_N.
DR PANTHER; PTHR13387; PTHR13387; 1.
DR Pfam; PF04063; DUF383; 1.
DR Pfam; PF04064; DUF384; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.3, ECO:0007744|PubMed:19413330"
FT CHAIN 2..390
FT /note="Protein HGH1 homolog"
FT /id="PRO_0000273318"
FT REGION 371..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylglycine"
FT /evidence="ECO:0000269|Ref.3, ECO:0007744|PubMed:19413330"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 214
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 388
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
SQ SEQUENCE 390 AA; 42129 MW; DC3AA4E92EA3761D CRC64;
MGEAGAGAGA SGGPEASPEA EVVKLLPFLA PGARADLQAA AVRHVLALTG CGPGRALLAG
QAALLQALME LAPASAPARD AARALVNLAA DPGLHETLLA ADPGLPARLM GRALDPQWPW
AEEAAAALAN LSREPAPCAA LMAALAAAEP ADSGLERLVR ALCTPGYNAR APLHYLAPLL
SNLSQRPAAR AFLLDPDRCV VQRLLPLTQY PDSSVRRGGV VGTLRNCCFE HRHHEWLLGP
EVDILPFLLL PLAGPEDFSE EEMERLPVDL QYLPPDKQRE PDADIRKMLV EAIMLLTATA
PGRQQVRDQG AYLILRELHS WEPEPDVRTA CEKLIQVLIG DEPERGMENL LEVQVPEDVE
QQLQQLDCRE QEQLERELAP EPWVERATPT
