HGH1_MOUSE
ID HGH1_MOUSE Reviewed; 393 AA.
AC Q8C3I8; Q9JJF4;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein HGH1 homolog;
GN Name=Hgh1; Synonyms=Brp16, Fam203a; ORFNames=MNCb-5873;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the HGH1 family. {ECO:0000305}.
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DR EMBL; AB041552; BAA95037.1; -; mRNA.
DR EMBL; AK085815; BAC39539.1; -; mRNA.
DR EMBL; BC061251; AAH61251.1; -; mRNA.
DR CCDS; CCDS27569.1; -.
DR RefSeq; NP_067530.2; NM_021555.2.
DR AlphaFoldDB; Q8C3I8; -.
DR SMR; Q8C3I8; -.
DR BioGRID; 208516; 31.
DR IntAct; Q8C3I8; 3.
DR MINT; Q8C3I8; -.
DR STRING; 10090.ENSMUSP00000023213; -.
DR iPTMnet; Q8C3I8; -.
DR PhosphoSitePlus; Q8C3I8; -.
DR EPD; Q8C3I8; -.
DR MaxQB; Q8C3I8; -.
DR PaxDb; Q8C3I8; -.
DR PeptideAtlas; Q8C3I8; -.
DR PRIDE; Q8C3I8; -.
DR ProteomicsDB; 269566; -.
DR Antibodypedia; 28319; 159 antibodies from 27 providers.
DR DNASU; 59053; -.
DR Ensembl; ENSMUST00000023213; ENSMUSP00000023213; ENSMUSG00000022554.
DR GeneID; 59053; -.
DR KEGG; mmu:59053; -.
DR UCSC; uc007wjz.2; mouse.
DR CTD; 51236; -.
DR MGI; MGI:1930628; Hgh1.
DR VEuPathDB; HostDB:ENSMUSG00000022554; -.
DR eggNOG; KOG2973; Eukaryota.
DR GeneTree; ENSGT00390000016546; -.
DR HOGENOM; CLU_037769_3_0_1; -.
DR InParanoid; Q8C3I8; -.
DR OMA; HRWEKDV; -.
DR OrthoDB; 1094436at2759; -.
DR PhylomeDB; Q8C3I8; -.
DR TreeFam; TF313296; -.
DR BioGRID-ORCS; 59053; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Hgh1; mouse.
DR PRO; PR:Q8C3I8; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q8C3I8; protein.
DR Bgee; ENSMUSG00000022554; Expressed in paneth cell and 225 other tissues.
DR Genevisible; Q8C3I8; MM.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039717; Hgh1.
DR InterPro; IPR007206; Protein_HGH1_C.
DR InterPro; IPR007205; Protein_HGH1_N.
DR PANTHER; PTHR13387; PTHR13387; 1.
DR Pfam; PF04063; DUF383; 1.
DR Pfam; PF04064; DUF384; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..393
FT /note="Protein HGH1 homolog"
FT /id="PRO_0000273319"
FT MOD_RES 221
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BTY7"
FT CONFLICT 72
FT /note="A -> S (in Ref. 1; BAA95037)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="Y -> C (in Ref. 1; BAA95037)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 393 AA; 42916 MW; 8B9F532A0EB2BBB1 CRC64;
MRGPGVGSGF SGERGLLEQE AGADTEAVEL LPFLVLGARA DLQAAAAQHV LALTGAGSGR
TLLAGQPELL RALVDLAVAP APAPSRDASR ALVNLAADPN VHWQLLAADP ELPARLLRCV
LDPQWPWAEE AAAVLANLSR EPAPCAALME KLMAAEPERL GLERLVNALC TPSYNAAAPL
HYLGPLLSNL SQQAEVRAFL LDPDRCVVQR LLPLTQYTDS SVRRGGVVGT LRNCCFEHRH
HKWLLGAQVD ILPFLLLPLA GPEEFSEEEM DQLPVDLQYL SPDKQREPDA DIRKMLIEAV
MLLTATAPGR KQVRDQGAYL ILRELHSWEP EPDVRMACEK LIQVLIGDEP EAGMENLLEV
QVPEDVEQQL QELDQQEQQE LAQELRGNGA PHT
