ID   HGP3_HAEIN              Reviewed;        1084 AA.
AC   P44836;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Probable hemoglobin and hemoglobin-haptoglobin-binding protein 3;
DE   Flags: Precursor;
GN   OrderedLocusNames=HI_0712;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Acts as a receptor for hemoglobin or the
CC       hemoglobin/haptoglobin complex of the human host and is required for
CC       heme uptake. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is subject to phase-variable expression
CC       associated with alteration in the length of the CCAA repeat region.
CC       This mechanism is called slipped-strand mispairing. Addition or loss of
CC       CCAA repeat units would change the reading frame and result in
CC       introduction of stop codons downstream of the repeat region. This may
CC       be a mechanism of regulation and a way to avoid the immunological
CC       response of the host (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L42023; AAC22369.1; -; Genomic_DNA.
DR   PIR; B64088; B64088.
DR   RefSeq; NP_438870.1; NC_000907.1.
DR   RefSeq; WP_010869038.1; NC_000907.1.
DR   AlphaFoldDB; P44836; -.
DR   SMR; P44836; -.
DR   STRING; 71421.HI_0712; -.
DR   PRIDE; P44836; -.
DR   EnsemblBacteria; AAC22369; AAC22369; HI_0712.
DR   KEGG; hin:HI_0712; -.
DR   PATRIC; fig|71421.8.peg.743; -.
DR   eggNOG; COG1629; Bacteria.
DR   eggNOG; COG4771; Bacteria.
DR   HOGENOM; CLU_008287_19_0_6; -.
DR   OMA; KYLPSYD; -.
DR   PhylomeDB; P44836; -.
DR   BioCyc; HINF71421:G1GJ1-746-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 2.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR006970; PT.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 2.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF04886; PT; 2.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Membrane; Receptor; Reference proteome; Repeat;
KW   Signal; TonB box; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..1084
FT                   /note="Probable hemoglobin and hemoglobin-haptoglobin-
FT                   binding protein 3"
FT                   /id="PRO_0000034787"
FT   REPEAT          26..29
FT                   /note="1"
FT   REPEAT          30..33
FT                   /note="2"
FT   REPEAT          34..37
FT                   /note="3"
FT   REPEAT          38..41
FT                   /note="4"
FT   REPEAT          42..45
FT                   /note="5"
FT   REPEAT          46..49
FT                   /note="6"
FT   REPEAT          50..53
FT                   /note="7"
FT   REPEAT          54..57
FT                   /note="8"
FT   REPEAT          58..61
FT                   /note="9"
FT   REPEAT          62..65
FT                   /note="10"
FT   REPEAT          66..69
FT                   /note="11"
FT   REPEAT          70..73
FT                   /note="12"
FT   REGION          26..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          26..73
FT                   /note="12 X 4 AA tandem repeats of Q-P-T-N"
FT   MOTIF           83..90
FT                   /note="TonB box"
FT   MOTIF           1067..1084
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   1084 AA;  123955 MW;  794DF91E0F53CFD9 CRC64;
     MTNFKFSLLA CSIAFALNAS TVYAAQPTNQ PTNQPTNQPT NQPTNQPTNQ PTNQPTNQPT
     NQPTNQPTNQ PTNQNSNVSE QLEQINVSGS SENINIKEKK VGETQISAKK LAKQQASDSR
     DLVRYETGIT VVETGRTGAS GYAVRGVDEN RVGIMVDGLR QAETLSSQGF KELFEGYGNF
     NNTRNSIEIE NVKTATITKG ADSLKSGSGA LGGSVIFETK DARDYLIDKD YYLSYKRGYQ
     TMNNQNLKTL TLAGRSKKFD ILIIDTTRDG HEIENYDYKI YPNKQADLRA VGPTREKADP
     YQITRQSTLI KLGFQPNENH RLSVALDDST LETKGIDLSY ALRPYSTAGN EKYGERIIND
     QSKRKNIQFS YENFSQTPFW DHIKLSYSSQ KITNKARSDE YCHQSTCNGV SNPQGLHLVE
     EGGVYKIVDK NGDKLTYNKN AGWYGQFQNK NGENVDNDID STGGSLDSVL IDCERLNCKN
     KFQVFVEKDE EGKDKYEYEE RDIIVETLPN GKKYGKITLK KGKTPLWDDV YQEESARFLF
     PKSYGYSTDF VNDRDLNTNT QQIKLDLDKE FSLWHTQHSL KYGGFYEKTL KSMVNHQYNT
     VANVQWWAGN FFCNKLENGK RTPAPDYSHR CSLMNTDKGK ETYLIPVTTK NNVLYFGDNV
     QLTSWLGLDL NYRYDHVKYL PSYDEKIPVP NGLITGLFKK FGPKDYVYGS KYSKPADYTD
     CTYNSDCYKK NFKDNLALLL RKTDYKHHSY NLGLNLDPTD WLRVQLKYAN GFRAPTSDEI
     YMTFKHPQFS IQPNTDLKAE TSKTKEVAFT FYKNSSYITL NAFQNDYRNF IDLVEVGPRP
     IEEGSTIAYP FHQNQNRDRA RVRGIEIASR LEMGDLFEKL QGFHLGYKFT YQKGRIKDNG
     LNPKYKEFLE LNKDKHPEYE AIARKPQPMN ALQPTTSVYN IGYDAPSQKW GVDMYITNVA
     AKKAKDSFNS QWTSMVKRKE KIYGNEKDAE ASTANGKEVK DSRGLWRNNR YTVIDTIAYW
     KPIKNLTFTA GVYNLTNKKY LTWDSARSIR HLGTINRVET ATGKGLNRFY APGRNYRMSV
     QFEF