HGPB_HAEIF
ID HGPB_HAEIF Reviewed; 999 AA.
AC O87296;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Hemoglobin and hemoglobin-haptoglobin-binding protein B;
DE Flags: Precursor;
GN Name=hgpB;
OS Haemophilus influenzae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=727;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HI689 / Serotype B;
RX PubMed=9746572; DOI=10.1128/iai.66.10.4733-4741.1998;
RA Ren Z., Jin H., Morton D.J., Stull T.L.;
RT "hgpB, a gene encoding a second Haemophilus influenzae hemoglobin- and
RT hemoglobin-haptoglobin-binding protein.";
RL Infect. Immun. 66:4733-4741(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=E1a / Serotype B;
RA Morton D.J., Stull T.L.;
RT "Conservation of hemoglobin/hemoglobin-haptoglobin binding proteins in
RT Haemophilus influenzae.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a receptor for hemoglobin or the
CC hemoglobin/haptoglobin complex of the human host and is required for
CC heme uptake.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- MISCELLANEOUS: This protein is subject to phase-variable expression
CC associated with alteration in the length of the CCAA repeat region.
CC This mechanism is called slipped-strand mispairing. Addition or loss of
CC CCAA repeat units would change the reading frame and result in
CC introduction of stop codons downstream of the repeat region. This may
CC be a mechanism of regulation and a way to avoid the immunological
CC response of the host.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
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DR EMBL; AF022910; AAC60790.1; -; Genomic_DNA.
DR EMBL; AF259266; AAK51630.1; -; Genomic_DNA.
DR AlphaFoldDB; O87296; -.
DR SMR; O87296; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProt.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR Gene3D; 2.170.130.10; -; 1.
DR Gene3D; 2.40.170.20; -; 2.
DR InterPro; IPR039426; BtuB-like.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR006970; PT.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR010949; TonB_Hb/transfer/lactofer_rcpt.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR PANTHER; PTHR30069; PTHR30069; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF04886; PT; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR TIGRFAMs; TIGR01786; TonB-hemlactrns; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Membrane; Receptor; Repeat; Signal; TonB box;
KW Transmembrane; Transmembrane beta strand; Transport.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..999
FT /note="Hemoglobin and hemoglobin-haptoglobin-binding
FT protein B"
FT /id="PRO_0000034779"
FT REPEAT 26..29
FT /note="1"
FT REPEAT 30..33
FT /note="2"
FT REPEAT 34..37
FT /note="3"
FT REPEAT 38..41
FT /note="4"
FT REPEAT 42..45
FT /note="5"
FT REPEAT 46..49
FT /note="6"
FT REPEAT 50..53
FT /note="7"
FT REPEAT 54..57
FT /note="8"
FT REGION 25..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 26..57
FT /note="8 X 4 AA tandem repeats of P-T-N-Q"
FT MOTIF 66..73
FT /note="TonB box"
FT MOTIF 982..999
FT /note="TonB C-terminal box"
FT VARIANT 46..57
FT /note="Missing (in strain: E1a)"
FT VARIANT 85
FT /note="I -> V (in strain: E1a)"
FT VARIANT 101
FT /note="D -> N (in strain: E1a)"
FT VARIANT 108
FT /note="T -> K (in strain: E1a)"
FT VARIANT 121..122
FT /note="LA -> FG (in strain: E1a)"
FT VARIANT 151
FT /note="T -> S (in strain: E1a)"
FT VARIANT 304
FT /note="G -> A (in strain: E1a)"
FT VARIANT 560
FT /note="N -> D (in strain: E1a)"
FT VARIANT 633
FT /note="L -> F (in strain: E1a)"
FT VARIANT 658
FT /note="R -> H (in strain: E1a)"
FT VARIANT 689
FT /note="K -> E (in strain: E1a)"
FT VARIANT 755
FT /note="A -> T (in strain: E1a)"
FT VARIANT 782
FT /note="S -> G (in strain: E1a)"
SQ SEQUENCE 999 AA; 114436 MW; 58F631FA5D2685B0 CRC64;
MTNFRLNVLA YSVMLGLTAS VAYAEPTNQP TNQPTNQPTN QPTNQPTNQP TNQPTNQNSN
ASEQLEQINV SGSTENTDTK APPKIAETVK TAKTLEREQA DNIKDIVTYE TGVTVVEAGR
LAQSGFAIRG VDENRVAINI DGLRQAETLS TQGFKELFEG YGNFNNTRNG AEIETLKEVN
ITKGADSIKN GSGSLGGSVI YKTKDARDYL INKDYYVSYK KGYATENNQS FNTLTLAGRY
KKFDVLVVTT SRNGHELENY GYKNYNDKIQ GKKREKADPY KIEQDSTLLK LSFNPTENHR
FTFGADLYEH RSRGQDLSYT LKYQKTDPNL AEVDSRHTND KTKRRNISFS YENFSQTPFW
DTLKITYSDQ RIKTRARTDE YCDAGVRHCE GTDNPTGLKV TDGKITRRDG SELQFEKKNN
TAHSNGETYD FKKFIDTDKK VIEDKLTLKN PNDTWYDCSI FNCENNAKIK VFEGNYSYGY
DGKWKEVDLE IKTLNGKKFA KIKDPTNKIK SILPSSPGYL ERLWQERDLD TNTQQLNLDL
TKDFKTWHIE HNLQYGGSYN TAMKRMVNRA GNDASDVQWW ATPTLGYNFY DQPYTCATAY
SWNANLCPRV DPEFSYLLPI KTTGKSVYLF DNLVITDYLS FDLGYRYDNI HYQPKYKRGI
TPKLPDDIVK GLFIPLPKNS NSKPDEVKKN VQQNIDYIAK QNKKYKAHSY SFVSTIDPTS
FLRLQLKYSK GFRTPTSDEM YFTFKHPDFT ILPNADLKPE IAKTKEIAFT LHNDDWGFIS
TSLFKTNYKN FIDLIFKGEK DFPLVSGGSS LPFSLYQNIN RDNASLKGIE INSKVFLGKM
AKFMDGFNLS YKYTYQKGRM NGNIPMNAIQ PRTMVYGLGY DHPNHKFGFD FYTTHVASKN
PEDTYDIYAK DKKQTDTSIK WRSKSYTILD LIGYVQPIKN LTIRAGVYNL TNRKYITWDS
ARSIRSFGTS NVIEQSTGLG INRFYAPGRN YKMSVQFEF
