ID   HGPC_HAEIF              Reviewed;        1066 AA.
AC   Q9X442;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Hemoglobin and hemoglobin-haptoglobin-binding protein C;
DE   Flags: Precursor;
GN   Name=hgpC;
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HI689 / Serotype B;
RX   PubMed=10338475; DOI=10.1128/iai.67.6.2729-2739.1999;
RA   Morton D.J., Whitby P.W., Stull T.L.;
RT   "Effect of multiple mutations in the hemoglobin- and hemoglobin-
RT   haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus
RT   influenzae type b.";
RL   Infect. Immun. 67:2729-2739(1999).
CC   -!- FUNCTION: Acts as a receptor for hemoglobin or the
CC       hemoglobin/haptoglobin complex of the human host and is required for
CC       heme uptake.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC   -!- MISCELLANEOUS: This protein is subject to phase-variable expression
CC       associated with alteration in the length of the CCAA repeat region.
CC       This mechanism is called slipped-strand mispairing. Addition or loss of
CC       CCAA repeat units would change the reading frame and result in
CC       introduction of stop codons downstream of the repeat region. This may
CC       be a mechanism of regulation and a way to avoid the immunological
CC       response of the host.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       Hemoglobin/haptoglobin binding protein subfamily. {ECO:0000305}.
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DR   EMBL; AF094574; AAD33112.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9X442; -.
DR   SMR; Q9X442; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProt.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 2.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR006970; PT.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF04886; PT; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Receptor; Repeat; Signal; TonB box;
KW   Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..1066
FT                   /note="Hemoglobin and hemoglobin-haptoglobin-binding
FT                   protein C"
FT                   /id="PRO_0000034780"
FT   REPEAT          26..29
FT                   /note="1"
FT   REPEAT          30..33
FT                   /note="2"
FT   REPEAT          34..37
FT                   /note="3"
FT   REPEAT          38..41
FT                   /note="4"
FT   REPEAT          42..45
FT                   /note="5"
FT   REPEAT          46..49
FT                   /note="6"
FT   REPEAT          50..53
FT                   /note="7"
FT   REGION          26..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          26..53
FT                   /note="7 X 4 AA tandem repeats of Q-P-T-N"
FT   MOTIF           63..70
FT                   /note="TonB box"
FT   MOTIF           1049..1066
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   1066 AA;  122594 MW;  EFB88D5CE4247583 CRC64;
     MTNFKFTLLA RSIAFALNAS TAYAAQPTNQ PTNQPTNQPT NQPTNQPTNQ PTNQDSNLSE
     QLEQINVSGS TETINVKEKK VGETQISAKK LAKQQASDSR DLVRYETGIT VVETGRTGAS
     GYAVRGVDEN RVGIMVDGLR QAETLSSQGF KELFEGYGNF NNTRNNIEIE NVKTATITKG
     ADSLKSGSGA LGGSVIFETK DARDYLIDKD YYVSYKRGYQ TMNNQNLKTL TLAGRSKKFD
     ILVVDTTRDG HEIENYDYKI YPNKQADLSA VGPTREKADP YQITRQSTLI KLGFQPNENH
     RLSVALDDST LETKGMDLSY AFRPYSQADK EIYGERIIND QSKRKNIQFS YENFSQTPFW
     DHIKLSYSSQ KITNKARSDE YCHQSTCNGV SNPQGLHLVE EKGVYKIVDK DNKDFNYQED
     KNNPWSYGKE LYNSKNEKIS NDVDTEGGAL DSVLINCEKL NCEKKKFPIY KEKDEEWKDK
     YEHEDRDITI KELNGKKYGE ISLKKSDSSG FTKYESARFL FPKSFGYSTD FVNDRDLNTN
     TQQIKLDLDK EFHLWHAQHQ LKYGGLYEKT LKSMVNHQYN TAANVQWWAD YFFCKKPVNG
     NRIPAPDHSA YRCKLMNSDI GKDTYLIPVT TKNNVLYFGD NVQLTSWLGL DLNYRYDHVK
     YLPSYDKNIP VPNGLITGLF KKFKSTDYVY GNKYLVPKGY TNCTYTTDCY KQNFEENLAL
     LLRKTDYKHH SYNLGLNLDP TNWLRVQLKY ANGFRAPTSD EIYMTFKHPQ FSIQPNTDLK
     AETSKTKEVA FTFYKNSSYI TLNAFQNDYR NFIDLVEVGE RPIEEGSVVR YPFHQNQNRD
     RARVRGIEIA SRLEMGDLLE KLQRFPLGYK FTYQKGRIKD NGLHPKYKEF LELNKDEHPE
     YEAIARKPQP MNALQPTTSV YNIGYDAPSQ KWGVDMYITN VAAKKAKDSF NSQWTSMVAR
     KEKIYDTEST VPAKKANGKE VKDSRGLWRN NRYTVIDTIA YWKPIKNLTF TAGVYNLTNK
     KYLTWDSARS VRHLGTINRV ETATGKGLNR LYAPGRNYRM SVQFEF