ID   HGV2_HALRO              Reviewed;         510 AA.
AC   Q02508;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Protein HGV2;
GN   Name=HGV2;
OS   Halocynthia roretzi (Sea squirt) (Cynthia roretzi).
OC   Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Stolidobranchia;
OC   Pyuridae; Halocynthia.
OX   NCBI_TaxID=7729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Oocyte;
RX   PubMed=8468323; DOI=10.1093/oxfordjournals.jbchem.a124024;
RA   Fujiwara S., Kawahara H., Makabe K.W., Satoh N.;
RT   "A complementary DNA for an ascidian embryonic nuclear antigen Hgv2 encodes
RT   a protein closely related to the amphibian histone-binding protein N1.";
RL   J. Biochem. 113:189-195(1993).
CC   -!- FUNCTION: May function as a nucleosome assembly factor during rapid
CC       embryonic cell divisions.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Embryo and larvae.
CC   -!- DEVELOPMENTAL STAGE: This protein is detected in the nuclei of all
CC       cells in embryos and larvae but is not detected in the cells of
CC       metamorphosed juveniles.
CC   -!- SIMILARITY: Belongs to the NASP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D13541; BAA02741.1; -; mRNA.
DR   PIR; JX0254; JX0254.
DR   AlphaFoldDB; Q02508; -.
DR   SMR; Q02508; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Repeat; TPR repeat.
FT   CHAIN           1..510
FT                   /note="Protein HGV2"
FT                   /id="PRO_0000083967"
FT   REPEAT          260..293
FT                   /note="TPR 1"
FT   REPEAT          302..335
FT                   /note="TPR 2"
FT   REGION          95..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..510
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           444..451
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           465..471
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        108..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..217
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..417
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..502
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   510 AA;  56872 MW;  D9961E5953E976FF CRC64;
     MVQDTEVVEA GTSKETETTV DVEKEIQECM GAGKKDLLCN DYSEAVNCFQ EACTLLSGKH
     GQMAEECCEA YYYYGVSLLE LARLENGVLG NALKGVPEED ADGDSDQEQE QFEKPDLPET
     EREKLREEVE AAMATEDEDT QEERGCPRRV EKKKEDDKPK ESEKSAEKSD EKEKEEKQAK
     VESSTVKDVK DEKSSDKPVE SSNTEEPGTS GTSASSSKEN ESEEDPDDIS NMQLAWEMLE
     LAKVLYKKHD KSKTNKQMVA QCHLKLGELG LEVENHPQAI GDFLECLVIQ KDLLPETDRK
     LAETYYNLGL AYSFEKRYDN ALEHYQSALD VLEARVDMLN ELIESNEGNK EKEKEIISEC
     KEVGELKELI PDINSKIEDV ILAKKQMQKL DGSPFRQASE GESSSGLGAS TSDDKPCSTI
     PIRKVAPTSV PVAKDSPSDI THLVRRKRPS PDEDNQPAES KENESKKAKQ EETEEATNGH
     SAVKKDTDVT DKNGTNGHSK TPKKDAAKRR