HHA_SHIFL
ID HHA_SHIFL Reviewed; 72 AA.
AC P0ACE6; P23870; P77120;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Hemolysin expression-modulating protein Hha;
GN Name=hha; OrderedLocusNames=SF0405, S0412;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Down-regulates hemolysin expression, in complex with H-NS,
CC and can also stimulate transposition events in vivo. Modifies the set
CC of genes regulated by H-NS; Hha and Cnu (YdgT) increase the number of
CC genes DNA bound by H-NS/StpA and may also modulate the oligomerization
CC of the H-NS/StpA-complex. Binds DNA and influences DNA topology in
CC response to environmental stimuli. Decreases biofilm formation (By
CC similarity). {ECO:0000250|UniProtKB:P0ACE3}.
CC -!- SUBUNIT: Forms a heterotrimeric complex with the H-NS dimer.
CC {ECO:0000250|UniProtKB:P0ACE3}.
CC -!- SIMILARITY: Belongs to the Hha/YmoA/Cnu family. {ECO:0000305}.
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DR EMBL; AE005674; AAN42060.2; -; Genomic_DNA.
DR EMBL; AE014073; AAP15937.1; -; Genomic_DNA.
DR RefSeq; NP_706353.2; NC_004337.2.
DR RefSeq; WP_001291435.1; NZ_WPGW01000015.1.
DR AlphaFoldDB; P0ACE6; -.
DR BMRB; P0ACE6; -.
DR SMR; P0ACE6; -.
DR STRING; 198214.SF0405; -.
DR EnsemblBacteria; AAN42060; AAN42060; SF0405.
DR EnsemblBacteria; AAP15937; AAP15937; S0412.
DR GeneID; 1027731; -.
DR GeneID; 66671238; -.
DR KEGG; sfl:SF0405; -.
DR KEGG; sfx:S0412; -.
DR PATRIC; fig|198214.7.peg.465; -.
DR HOGENOM; CLU_190629_0_0_6; -.
DR OMA; RRCQSID; -.
DR OrthoDB; 1919885at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1280.40; -; 1.
DR InterPro; IPR007985; Hemolysn_expr_modulating_HHA.
DR InterPro; IPR036666; HHA_sf.
DR Pfam; PF05321; HHA; 1.
DR SUPFAM; SSF68989; SSF68989; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..72
FT /note="Hemolysin expression-modulating protein Hha"
FT /id="PRO_0000201730"
FT SITE 25
FT /note="Interacts with H-NS"
FT /evidence="ECO:0000250"
FT SITE 48
FT /note="Interacts with H-NS"
FT /evidence="ECO:0000250"
SQ SEQUENCE 72 AA; 8628 MW; A77211B87CF0134A CRC64;
MSEKPLTKTD YLMRLRRCQT IDTLERVIEK NKYELSDNEL AVFYSAADHR LAELTMNKLY
DKIPSSVWKF IR
