HHEXH_CAEEL
ID HHEXH_CAEEL Reviewed; 214 AA.
AC Q21578;
DT 03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT 11-NOV-2015, sequence version 5.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Homeobox protein HEX homolog pha-2 {ECO:0000305};
DE AltName: Full=Defective pharyngeal development protein 2 {ECO:0000312|WormBase:M6.3};
GN Name=pha-2 {ECO:0000312|WormBase:M6.3};
GN ORFNames=M6.3 {ECO:0000312|WormBase:M6.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=15282157; DOI=10.1016/j.ydbio.2004.05.011;
RA Moerck C., Rauthan M., Waagberg F., Pilon M.;
RT "pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and
RT is required for the formation of the pharyngeal isthmus.";
RL Dev. Biol. 272:403-418(2004).
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=16806153; DOI=10.1016/j.ydbio.2006.05.020;
RA Moerck C., Axaeng C., Goksoer M., Pilon M.;
RT "Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant
RT accompanies ultrastructural defects in pharyngeal muscle cells.";
RL Dev. Biol. 297:446-460(2006).
CC -!- FUNCTION: Transcriptional repressor (By similarity). Involved in
CC pharyngeal development and required for the formation of the pharyngeal
CC isthmus (PubMed:15282157, PubMed:16806153). Plays a role in modulating
CC cytoskeleton in the muscle cells of the isthmus (PubMed:16806153).
CC Regulates expression of the acetylcholinesterase genes ace-1 and ace-2
CC (PubMed:16806153). May regulate its own expression (PubMed:15282157).
CC {ECO:0000250|UniProtKB:P43120, ECO:0000269|PubMed:15282157,
CC ECO:0000269|PubMed:16806153}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|RuleBase:RU000682, ECO:0000269|PubMed:15282157}.
CC -!- DEVELOPMENTAL STAGE: Earliest expression in 4-8 cells of the pharyngeal
CC primordium at around 280-300 min of embryonic development
CC (PubMed:15282157). Expressed just before the comma stage (approximately
CC 350 min) in two groups of pharyngeal primordium cells, persisting until
CC the 3-fold stage (PubMed:15282157). At the 3-fold stage, expressed in
CC several cells of the tail; expression continues in larvae and adults in
CC several cells of the head, including at least two amphid neurons,
CC intestinal cells, three rectal gland cells and 1-2 other unidentified
CC rectal cells (PubMed:15282157). {ECO:0000269|PubMed:15282157}.
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DR EMBL; BX284606; CCD69443.2; -; Genomic_DNA.
DR RefSeq; NP_508131.4; NM_075730.6.
DR AlphaFoldDB; Q21578; -.
DR SMR; Q21578; -.
DR IntAct; Q21578; 1.
DR STRING; 6239.M6.3; -.
DR EPD; Q21578; -.
DR PaxDb; Q21578; -.
DR EnsemblMetazoa; M6.3.1; M6.3.1; WBGene00004011.
DR GeneID; 187454; -.
DR KEGG; cel:CELE_M6.3; -.
DR UCSC; M6.3; c. elegans.
DR CTD; 187454; -.
DR WormBase; M6.3; CE50536; WBGene00004011; pha-2.
DR eggNOG; KOG0483; Eukaryota.
DR GeneTree; ENSGT00940000164435; -.
DR HOGENOM; CLU_1416315_0_0_1; -.
DR InParanoid; Q21578; -.
DR OMA; FNPWICH; -.
DR OrthoDB; 1438650at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00004011; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:WormBase.
DR GO; GO:0009887; P:animal organ morphogenesis; IMP:WormBase.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0042755; P:eating behavior; IMP:WormBase.
DR GO; GO:0042694; P:muscle cell fate specification; IMP:WormBase.
DR GO; GO:0002119; P:nematode larval development; IGI:WormBase.
DR GO; GO:1905905; P:pharyngeal gland morphogenesis; IMP:UniProtKB.
DR GO; GO:0043282; P:pharyngeal muscle development; IMP:WormBase.
DR GO; GO:0040014; P:regulation of multicellular organism growth; IMP:WormBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:WormBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..214
FT /note="Homeobox protein HEX homolog pha-2"
FT /id="PRO_0000456206"
FT DNA_BIND 124..183
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 214 AA; 24520 MW; 3AC3468CAE45832E CRC64;
MDQKFYISSL LQEDTPSKEK PETSSESPIP TGSECSLNES SDTTLDQKME PNKKMFNGTL
DFNPWICHVS QQLAAQLSQN GKNRPGAPNQ VPLLNMNVNQ TMGNMWDPRL SWLYPYMSKS
PQKRKGGQIR FTNEQTDALE HKFDSHKYLS PQERKKLAKS LSLSERQVKT WFQNRRAKWR
RVRKDGEDED EMPNGASARS LGQLQSSNPF LSHG
