ID   HHEX_CHICK              Reviewed;         277 AA.
AC   Q05502;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Hematopoietically-expressed homeobox protein HHEX;
DE            Short=Homeobox protein HEX;
DE   AltName: Full=Homeobox protein PRH;
GN   Name=HHEX; Synonyms=PRH;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DNA-BINDING, AND TISSUE SPECIFICITY.
RC   TISSUE=Monoblast;
RX   PubMed=1360645; DOI=10.1093/nar/20.21.5661;
RA   Crompton M.R., Bartlett T.J., Macgregor A.D., Manfioletti G., Buratti E.,
RA   Giancotti V., Goodwin G.H.;
RT   "Identification of a novel vertebrate homeobox gene expressed in
RT   haematopoietic cells.";
RL   Nucleic Acids Res. 20:5661-5667(1992).
CC   -!- FUNCTION: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional
CC       repressor. May play a role in hematopoietic differentiation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: In all hematopoietic tissues except peripheral
CC       blood erythrocytes and in the liver and lung.
CC       {ECO:0000269|PubMed:1360645}.
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DR   EMBL; X64711; CAA45966.1; -; mRNA.
DR   PIR; S78063; S78063.
DR   RefSeq; NP_990583.1; NM_205252.1.
DR   AlphaFoldDB; Q05502; -.
DR   SMR; Q05502; -.
DR   STRING; 9031.ENSGALP00000041279; -.
DR   PaxDb; Q05502; -.
DR   PRIDE; Q05502; -.
DR   GeneID; 396182; -.
DR   KEGG; gga:396182; -.
DR   CTD; 3087; -.
DR   VEuPathDB; HostDB:geneid_396182; -.
DR   eggNOG; KOG0483; Eukaryota.
DR   InParanoid; Q05502; -.
DR   OrthoDB; 1596695at2759; -.
DR   PhylomeDB; Q05502; -.
DR   PRO; PR:Q05502; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; DNA-binding; Homeobox; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..277
FT                   /note="Hematopoietically-expressed homeobox protein HHEX"
FT                   /id="PRO_0000049073"
FT   DNA_BIND        144..203
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          47..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          199..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..65
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        199..223
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   277 AA;  30214 MW;  BE744C143FB9F9FC CRC64;
     MQYQAPGAAP AAALGVGVPL YAPTPLLQPA HPTPFYIEDI LGRGPAAAPA PHSLPAPPPP
     TLPSPNSSFT SLVAPYRTPV YEPTPIHPAF SHHLAATYGT GAYAGPLYSF PRAVGDYTHA
     LIRQDPLGKP LLWSPFIQRP LHKRKGGQVR FSNEQTIELE KKFETQKYLS PPERKRLAKL
     LQLSERQVKT WFQNRRAKWR RLKQENPQAT KKEEAEGTGD HGDPRSEGSP SPAGGGEAEP
     QDSPSAASQE DPESDVSDDS DQEVDIEGDK GFYSATR