ID   HHEX_PATMI              Reviewed;         280 AA.
AC   D2KQB0; B2KTD6;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Hematopoietically-expressed homeobox protein HHEX homolog;
DE            Short=AmHEX {ECO:0000303|PubMed:19941847};
DE            Short=Homeobox protein HEX {ECO:0000250|UniProtKB:Q03014};
DE   AltName: Full=HEX homeodomain transcription factor;
GN   Name=hhex {ECO:0000250|UniProtKB:Q9IAV3};
GN   Synonyms=hex {ECO:0000303|PubMed:19941847};
OS   Patiria miniata (Bat star) (Asterina miniata).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC   Valvatacea; Valvatida; Asterinidae; Patiria.
OX   NCBI_TaxID=46514;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ADA79643.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula {ECO:0000269|PubMed:19941847};
RX   PubMed=19941847; DOI=10.1016/j.ydbio.2009.11.020;
RA   McCauley B.S., Weideman E.P., Hinman V.F.;
RT   "A conserved gene regulatory network subcircuit drives different
RT   developmental fates in the vegetal pole of highly divergent echinoderm
RT   embryos.";
RL   Dev. Biol. 340:200-208(2010).
RN   [2] {ECO:0000305, ECO:0000312|EMBL:ABY60803.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 34-240.
RX   PubMed=18413604; DOI=10.1073/pnas.0801201105;
RA   Gao F., Davidson E.H.;
RT   "Transfer of a large gene regulatory apparatus to a new developmental
RT   address in echinoid evolution.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:6091-6096(2008).
CC   -!- FUNCTION: Transcription factor that may play a central role in
CC       activating or maintaining gene expression in the vegetal pole. Part of
CC       a gene regulatory circuit with Erg and Tgif that operates early in
CC       mesoderm development. {ECO:0000269|PubMed:19941847,
CC       ECO:0000303|PubMed:19941847}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:19941847}.
CC   -!- DEVELOPMENTAL STAGE: At the blastula stage, expressed within the
CC       vegetal pole domain and throughout the cells fated to become the
CC       endomesoderm. By mid-gastrula, expressed throughout the archenteron,
CC       with some clearing evident at the tip of the mesodermal bulb. Expressed
CC       at the larvae spines. {ECO:0000269|PubMed:18413604,
CC       ECO:0000269|PubMed:19941847}.
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DR   EMBL; GU251972; ADA79643.1; -; mRNA.
DR   EMBL; EU196052; ABY60803.1; -; mRNA.
DR   AlphaFoldDB; D2KQB0; -.
DR   SMR; D2KQB0; -.
DR   OMA; YPHGLID; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..280
FT                   /note="Hematopoietically-expressed homeobox protein HHEX
FT                   homolog"
FT                   /id="PRO_0000419636"
FT   DNA_BIND        165..224
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..35
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..253
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  31081 MW;  F46961E25569A212 CRC64;
     MSTLQYPGPP PPSSMNLHNP HMNHHHGLVG PGLAPLSAPN GIQSLNTLHN GSGPPSHTPF
     YIDNILGSRL NMTGPARPTP TLPSPTFPAH MNSAYNSYYE QAVHPGLAAP TPISYGSGAF
     SSPPPYPFAR GDYPHGLIDR HDPYSKVPGK PFLWNPFIQR PLHKRKGGQV RFSNDQTMEL
     EKKFESQKYL SPPERKKLAK LLQLSERQVK TWFQNRRAKW RRVKQEVPTG KGEGDENSHE
     KPRDLDRDDF SREQVLSNGA ACAFTHGGGS EADSLEEKEA