HHEX_XENTR
ID HHEX_XENTR Reviewed; 274 AA.
AC Q8AWG6;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Hematopoietically-expressed homeobox protein hhex;
DE Short=Homeobox protein hex;
DE Short=tHex;
GN Name=hhex {ECO:0000312|EMBL:CAJ83926.1};
GN Synonyms=hex {ECO:0000312|EMBL:AAN78202.1}; ORFNames=TGas075h17.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAN78202.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAN78202.1};
RX PubMed=12508233; DOI=10.1002/dvdy.10201;
RA D'Souza A., Lee M., Taverner N., Mason J., Carruthers S., Smith J.C.,
RA Amaya E., Papalopulu N., Zorn A.M.;
RT "Molecular components of the endoderm specification pathway in Xenopus
RT tropicalis.";
RL Dev. Dyn. 226:118-127(2003).
RN [2] {ECO:0000312|EMBL:CAJ83926.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83926.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional
CC repressor. Regulates the differentiation of both endothelial and blood
CC cells. Probably plays a role in the proliferation of vascular
CC endothelial cells during blood vessel development. Establishes anterior
CC identity at two levels; acts early to enhance canonical wnt-signaling
CC by repressing expression of tle4, and acts later to inhibit nodal-
CC signaling by directly targeting nodal/nr1 and nodal2/nr2. May play a
CC role in liver development. Induces heart development (By similarity).
CC {ECO:0000250|UniProtKB:O13023, ECO:0000250|UniProtKB:Q05502,
CC ECO:0000250|UniProtKB:Q9IAV3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255, ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the most dorsoanterior endomesoderm of
CC the blastula and gastrula embryo, and later is restricted to the
CC forming liver diverticulum. {ECO:0000269|PubMed:12508233}.
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DR EMBL; AY160969; AAN78202.1; -; mRNA.
DR EMBL; CR761571; CAJ83926.1; -; mRNA.
DR RefSeq; NP_989420.1; NM_204089.1.
DR AlphaFoldDB; Q8AWG6; -.
DR SMR; Q8AWG6; -.
DR STRING; 8364.ENSXETP00000057734; -.
DR PaxDb; Q8AWG6; -.
DR PRIDE; Q8AWG6; -.
DR Ensembl; ENSXETT00000057734; ENSXETP00000057734; ENSXETG00000012215.
DR GeneID; 395060; -.
DR KEGG; xtr:395060; -.
DR CTD; 3087; -.
DR Xenbase; XB-GENE-487159; hhex.
DR eggNOG; KOG0483; Eukaryota.
DR InParanoid; Q8AWG6; -.
DR OrthoDB; 1596695at2759; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000012215; Expressed in liver and 18 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0035162; P:embryonic hemopoiesis; ISS:UniProtKB.
DR GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR GO; GO:0001889; P:liver development; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001570; P:vasculogenesis; ISS:UniProtKB.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Repressor; Transcription; Transcription regulation; Wnt signaling pathway.
FT CHAIN 1..274
FT /note="Hematopoietically-expressed homeobox protein hhex"
FT /id="PRO_0000326221"
FT DNA_BIND 139..198
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 197..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..235
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 274 AA; 30873 MW; 24DFCD385C9A6AA6 CRC64;
MQYQHPSSSA LGLSVPLYAP TPLQPVHPTP FYIDDILGRS SASNGTPALP TPTLPSPNSS
FTSLVATYRT PIYEPTPIHP AFTHPGAALA ASYGASTYAN PLYPFSRPVS EYTHALIRHD
TLGKPLLWSP FIQRPLHKRK GGQVRFSNDQ TIELEKKFET QKYLSPPERK RLAKMLQLSE
RQVKTWFQNR RAKWRRLKQE NPQGNKKDET ESLENICEES QERCLSAEQK SRESSLDEPT
SSPTSQETLD SEVSDDSDQE VDIEGDKGFY NCAH
