HHL1_ARATH
ID HHL1_ARATH Reviewed; 231 AA.
AC Q8LDL0; F4HTQ4; Q94A67;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Protein HHL1, chloroplastic {ECO:0000305};
DE AltName: Full=Hypersensitive to high light 1 {ECO:0000303|PubMed:24632535};
DE Flags: Precursor;
GN Name=HHL1 {ECO:0000303|PubMed:24632535};
GN OrderedLocusNames=At1g67700 {ECO:0000312|Araport:AT1G67700};
GN ORFNames=F12A21.30 {ECO:0000312|EMBL:AC008113};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAM63154.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, INTERACTION WITH LQY1; PSBB AND PSBC, AND
RP INDUCTION.
RX PubMed=24632535; DOI=10.1105/tpc.113.122424;
RA Jin H., Liu B., Luo L., Feng D., Wang P., Liu J., Da Q., He Y., Qi K.,
RA Wang J., Wang H.B.;
RT "HYPERSENSITIVE TO HIGH LIGHT1 interacts with LOW QUANTUM YIELD OF
RT PHOTOSYSTEM II1 and functions in protection of photosystem II from
RT photodamage in Arabidopsis.";
RL Plant Cell 26:1213-1229(2014).
CC -!- FUNCTION: Involved in photoprotection. Forms a complex with LQY1 that
CC is involved in the repair and reassembly cycle of the PSII-LHCII
CC supercomplex under high-light conditions. May function in guiding the
CC release of psbC from PSII core monomers. {ECO:0000269|PubMed:24632535}.
CC -!- SUBUNIT: Interacts with psbB, psbC and LQY1, but not with psbA or psbD
CC (PubMed:24632535). {ECO:0000269|PubMed:24632535}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane
CC {ECO:0000269|PubMed:24632535}; Single-pass membrane protein
CC {ECO:0000305}. Note=Found in the stroma lamellae > grana margin > grana
CC core. {ECO:0000269|PubMed:24632535}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8LDL0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8LDL0-2; Sequence=VSP_057473;
CC Name=3;
CC IsoId=Q8LDL0-3; Sequence=VSP_057472, VSP_057473;
CC -!- INDUCTION: Not regulated at the transcription level by high light.
CC {ECO:0000269|PubMed:24632535}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, when grown under normal
CC light conditions. Partial loss of PSII capacity after high-light
CC stress. {ECO:0000269|PubMed:24632535}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC008113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE34683.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34684.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34685.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59871.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM59872.1; -; Genomic_DNA.
DR EMBL; AK316962; BAH19661.1; -; mRNA.
DR EMBL; AY050331; AAK91348.1; -; mRNA.
DR EMBL; AY116936; AAM51570.1; -; mRNA.
DR EMBL; AY085943; AAM63154.1; -; mRNA.
DR RefSeq; NP_001185346.1; NM_001198417.1. [Q8LDL0-3]
DR RefSeq; NP_001319335.1; NM_001334319.1. [Q8LDL0-2]
DR RefSeq; NP_001319336.1; NM_001334320.1. [Q8LDL0-1]
DR RefSeq; NP_564903.3; NM_105438.6. [Q8LDL0-1]
DR RefSeq; NP_850972.1; NM_180641.4. [Q8LDL0-2]
DR AlphaFoldDB; Q8LDL0; -.
DR STRING; 3702.AT1G67700.2; -.
DR iPTMnet; Q8LDL0; -.
DR PaxDb; Q8LDL0; -.
DR PRIDE; Q8LDL0; -.
DR ProteomicsDB; 230221; -. [Q8LDL0-1]
DR EnsemblPlants; AT1G67700.1; AT1G67700.1; AT1G67700. [Q8LDL0-2]
DR EnsemblPlants; AT1G67700.2; AT1G67700.2; AT1G67700. [Q8LDL0-1]
DR EnsemblPlants; AT1G67700.3; AT1G67700.3; AT1G67700. [Q8LDL0-3]
DR EnsemblPlants; AT1G67700.4; AT1G67700.4; AT1G67700. [Q8LDL0-2]
DR EnsemblPlants; AT1G67700.5; AT1G67700.5; AT1G67700. [Q8LDL0-1]
DR GeneID; 843095; -.
DR Gramene; AT1G67700.1; AT1G67700.1; AT1G67700. [Q8LDL0-2]
DR Gramene; AT1G67700.2; AT1G67700.2; AT1G67700. [Q8LDL0-1]
DR Gramene; AT1G67700.3; AT1G67700.3; AT1G67700. [Q8LDL0-3]
DR Gramene; AT1G67700.4; AT1G67700.4; AT1G67700. [Q8LDL0-2]
DR Gramene; AT1G67700.5; AT1G67700.5; AT1G67700. [Q8LDL0-1]
DR KEGG; ath:AT1G67700; -.
DR Araport; AT1G67700; -.
DR TAIR; locus:2008615; AT1G67700.
DR eggNOG; KOG2089; Eukaryota.
DR InParanoid; Q8LDL0; -.
DR OMA; DPDNEQF; -.
DR OrthoDB; 1293496at2759; -.
DR PhylomeDB; Q8LDL0; -.
DR PRO; PR:Q8LDL0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LDL0; baseline and differential.
DR Genevisible; Q8LDL0; AT.
DR GO; GO:0009507; C:chloroplast; HDA:TAIR.
DR GO; GO:0009941; C:chloroplast envelope; HDA:TAIR.
DR GO; GO:0009534; C:chloroplast thylakoid; HDA:TAIR.
DR GO; GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0003729; F:mRNA binding; IDA:TAIR.
DR InterPro; IPR045388; HHL1-like.
DR PANTHER; PTHR48191; PTHR48191; 1.
DR Pfam; PF20133; DUF6523; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chloroplast; Membrane; Plastid; Reference proteome;
KW Thylakoid; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..39
FT /note="Chloroplast"
FT /evidence="ECO:0000305"
FT CHAIN 40..231
FT /note="Protein HHL1, chloroplastic"
FT /id="PRO_0000431978"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 206..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 166
FT /note="Missing (in isoform 3)"
FT /id="VSP_057472"
FT VAR_SEQ 231
FT /note="Missing (in isoform 2 and isoform 3)"
FT /id="VSP_057473"
SQ SEQUENCE 231 AA; 26081 MW; 99271FD460AD5994 CRC64;
MEVSMSLNAL TRLPLKNTGR FEEVGLARHS LFSSRTACRE TAVQQRRMVF VVEAKGKKGM
AARQYQRTPP PMPKIEDDGN PRFVIFIRMA NVYLWYPLSI IAGGTTAKIM VAAKDNLLGK
YIYKDTIARN IAAVIYRDEK EIQKTAIKQH RVLRTATEFR YGYKLVENGN MRAALSTSDV
IELPTQDQLK TVFDKVKDYF GDAKESFGKL SSLNPGSDEK TEETSDEKAK A
