HHLA1_MOUSE
ID HHLA1_MOUSE Reviewed; 514 AA.
AC Q3TYV2;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=HERV-H LTR-associating protein 1 homolog;
DE Flags: Precursor;
GN Name=Hhla1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Inner ear;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; AK158329; BAE34460.1; -; mRNA.
DR CCDS; CCDS49618.1; -.
DR RefSeq; NP_001138568.1; NM_001145096.1.
DR AlphaFoldDB; Q3TYV2; -.
DR STRING; 10090.ENSMUSP00000098149; -.
DR GlyGen; Q3TYV2; 9 sites.
DR iPTMnet; Q3TYV2; -.
DR PhosphoSitePlus; Q3TYV2; -.
DR PaxDb; Q3TYV2; -.
DR PRIDE; Q3TYV2; -.
DR Antibodypedia; 67806; 23 antibodies from 10 providers.
DR Ensembl; ENSMUST00000100584; ENSMUSP00000098149; ENSMUSG00000072511.
DR GeneID; 654498; -.
DR KEGG; mmu:654498; -.
DR UCSC; uc007waa.1; mouse.
DR CTD; 10086; -.
DR MGI; MGI:3615329; Hhla1.
DR VEuPathDB; HostDB:ENSMUSG00000072511; -.
DR eggNOG; ENOG502S3MP; Eukaryota.
DR GeneTree; ENSGT00530000064699; -.
DR HOGENOM; CLU_042998_0_0_1; -.
DR InParanoid; Q3TYV2; -.
DR OrthoDB; 798062at2759; -.
DR PhylomeDB; Q3TYV2; -.
DR TreeFam; TF341554; -.
DR BioGRID-ORCS; 654498; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Hhla1; mouse.
DR PRO; PR:Q3TYV2; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q3TYV2; protein.
DR Bgee; ENSMUSG00000072511; Expressed in secondary oocyte and 3 other tissues.
DR ExpressionAtlas; Q3TYV2; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR037643; HHLA1.
DR PANTHER; PTHR15299; PTHR15299; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..514
FT /note="HERV-H LTR-associating protein 1 homolog"
FT /id="PRO_0000394220"
FT REGION 379..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 232
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 321
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 514 AA; 56354 MW; 0C016E44F58A7BD2 CRC64;
MQSFLLHCPP IRLCMGLACI LFLWNAVSGL KGEGKKDKEM ALPPATVSGN EGLKKEKNGS
FLHAAESVFK EKKMVKGLEV LATTELPARS VDLSTLNLTE LVNGMLNRAL KDSKQFFSVL
SITSYSSFAF HKVSVAIYNI SNPKTVDPAK FPTRHCYCLS NRTNDLSDFT ALLVDIVGNS
TSYLTEIFKS TSILSVTQTN ESDCVFICVM VGKSGRNLSD FWEMVEKSPV INYTFTSGVS
SVLATTRGTA RTSRLTTQSQ QSLLRPYSVR WSTQWVSALK SLPWTKTSAP SEKELAESKQ
MFPELPVGTI GTHSSAPSSS NMTRTPWGTN RYTQAPTVPM PMPLSVDDST PEGPPWASLP
STSASIEDAQ QLRSTGNLLH PTGILTTPSR LAQPSRASGT LMPGTQTTNP TQAPAPRVPQ
TDGIPAEWPF IPEKEPARDP AAHQVSKCPR PLLQEEAITD TPLPLAMKKL TPCLMELCRF
FQQCLCAIQK RDFSSEAISN CYLPEKIRKL ITLH
