HHO1_ARATH
ID HHO1_ARATH Reviewed; 357 AA.
AC Q9LS00; Q8LE82;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Transcription factor HHO1 {ECO:0000305};
DE AltName: Full=MYB-domain transcription factor HHO1 {ECO:0000305};
DE AltName: Full=Protein HRS1 HOMOLOG 1 {ECO:0000303|PubMed:25723764};
GN Name=HHO1 {ECO:0000303|PubMed:25723764};
GN OrderedLocusNames=At3g25790 {ECO:0000312|Araport:AT3G25790};
GN ORFNames=K13N2.13 {ECO:0000312|EMBL:BAA95766.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION BY NITRATE.
RX PubMed=25723764; DOI=10.1038/ncomms7274;
RA Medici A., Marshall-Colon A., Ronzier E., Szponarski W., Wang R., Gojon A.,
RA Crawford N.M., Ruffel S., Coruzzi G.M., Krouk G.;
RT "AtNIGT1/HRS1 integrates nitrate and phosphate signals at the Arabidopsis
RT root tip.";
RL Nat. Commun. 6:6274-6274(2015).
RN [5]
RP INDUCTION.
RX PubMed=27419465; DOI=10.1111/tpj.13272;
RA Menz J., Li Z., Schulze W.X., Ludewig U.;
RT "Early nitrogen-deprivation responses in Arabidopsis roots reveal distinct
RT differences on transcriptome and (phospho-) proteome levels between nitrate
RT and ammonium nutrition.";
RL Plant J. 88:717-734(2016).
CC -!- FUNCTION: Probable factor involved in nitrate and phosphate signaling
CC in roots. Integrates nitrate and phosphate starvation responses and
CC adaptation of root architecture, depending on nutrient availabilities.
CC Acts downstream of the nitrate sensor and transporter NPF6.3/NRT1.1.
CC Represses primary root development in response to phosphate deficiency
CC conditions, only when nitrate is present.
CC {ECO:0000269|PubMed:25723764}.
CC -!- INTERACTION:
CC Q9LS00; O80340: ERF4; NbExp=5; IntAct=EBI-15203988, EBI-966009;
CC Q9LS00; Q9MAI5: ERF8; NbExp=4; IntAct=EBI-15203988, EBI-2000137;
CC Q9LS00; O24410: IAA20; NbExp=3; IntAct=EBI-15203988, EBI-632272;
CC Q9LS00; Q9FKM7: IAA33; NbExp=3; IntAct=EBI-15203988, EBI-3946739;
CC Q9LS00; Q9FNZ4: NIMIN-3; NbExp=3; IntAct=EBI-15203988, EBI-541115;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:25723764}.
CC -!- INDUCTION: Induced by nitrate (PubMed:25723764). Down-regulated under
CC nitrate deprivation conditions (PubMed:27419465).
CC {ECO:0000269|PubMed:25723764, ECO:0000269|PubMed:27419465}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM62792.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB028607; BAA95766.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77068.1; -; Genomic_DNA.
DR EMBL; AY085570; AAM62792.1; ALT_INIT; mRNA.
DR RefSeq; NP_566778.1; NM_113478.2.
DR AlphaFoldDB; Q9LS00; -.
DR SMR; Q9LS00; -.
DR IntAct; Q9LS00; 19.
DR STRING; 3702.AT3G25790.1; -.
DR PaxDb; Q9LS00; -.
DR PRIDE; Q9LS00; -.
DR EnsemblPlants; AT3G25790.1; AT3G25790.1; AT3G25790.
DR GeneID; 822170; -.
DR Gramene; AT3G25790.1; AT3G25790.1; AT3G25790.
DR KEGG; ath:AT3G25790; -.
DR Araport; AT3G25790; -.
DR TAIR; locus:2085984; AT3G25790.
DR eggNOG; ENOG502QSXV; Eukaryota.
DR HOGENOM; CLU_036551_0_0_1; -.
DR InParanoid; Q9LS00; -.
DR OMA; GIYGPMV; -.
DR OrthoDB; 907731at2759; -.
DR PhylomeDB; Q9LS00; -.
DR PRO; PR:Q9LS00; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LS00; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0016036; P:cellular response to phosphate starvation; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0090548; P:response to nitrate starvation; IMP:UniProtKB.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044787; HRS1-like.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR PANTHER; PTHR31003; PTHR31003; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..357
FT /note="Transcription factor HHO1"
FT /id="PRO_0000439544"
FT DOMAIN 193..253
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 224..249
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 94..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..114
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 296
FT /note="E -> ET (in Ref. 3; AAM62792)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 357 AA; 40370 MW; 9FE588D03ABBDFFA CRC64;
MIKNLSNMKN DNQKREKCCE YIEALEEERR KINVFQRELP LCVELVTQAI EAYKREISGT
STDNLYGQSE CSEQTTGECG RILDLFIPIK HSSTSIEEEV DDKDDDDEEH QSHETDIDFD
DKNMKSEWLK SVQLWNQSDA VVSNNRQDRS QEKTETLVEL IKINDEAAKK NNNIKSPVTT
SDGGSGGGGG RRGQRKNRRC WSQELHRRFL NALKQLGGPH VATPKQIRDI MKVDGLTNDE
VKSHLQKYRL HARRPSQTTP NNRNSQTQHF VVVGGIWVPQ TNHSTANAVN AVASGETTGI
YGPMVSSLPS EWPRHSNFGR KISEDRSRCS NNGFFRCSSP AMSCSTRTKT KDAKIIS
