HHO2_ARATH
ID HHO2_ARATH Reviewed; 354 AA.
AC Q8VZS3; Q8LA71; Q9SX30;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Transcription factor HHO2 {ECO:0000305};
DE AltName: Full=MYB-domain transcription factor HHO2 {ECO:0000305};
DE AltName: Full=Protein HRS1 HOMOLOG 2 {ECO:0000303|PubMed:27016098};
GN Name=HHO2 {ECO:0000303|PubMed:27016098};
GN OrderedLocusNames=At1g68670 {ECO:0000312|Araport:AT1G68670};
GN ORFNames=F24J5.9 {ECO:0000312|EMBL:AAD49976.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=27016098; DOI=10.1093/pcp/pcw063;
RA Nagarajan V.K., Satheesh V., Poling M.D., Raghothama K.G., Jain A.;
RT "Arabidopsis MYB-related HHO2 exerts a regulatory influence on a subset of
RT root traits and genes governing phosphate homeostasis.";
RL Plant Cell Physiol. 57:1142-1152(2016).
CC -!- FUNCTION: Probable transcription factor involved in phosphate
CC homeostasis. Involved in the regulation of the developmental response
CC of lateral roots, acquisition and/or mobilization of phosphate and
CC expression of a subset of genes involved in phosphate sensing and
CC signaling pathway. Is a target of the transcription factor PHR1.
CC {ECO:0000269|PubMed:27016098}.
CC -!- INTERACTION:
CC Q8VZS3; O80340: ERF4; NbExp=3; IntAct=EBI-4429217, EBI-966009;
CC Q8VZS3; Q9MAI5: ERF8; NbExp=3; IntAct=EBI-4429217, EBI-2000137;
CC Q8VZS3; P93830: IAA17; NbExp=3; IntAct=EBI-4429217, EBI-632243;
CC Q8VZS3; Q9FNZ4: NIMIN-3; NbExp=3; IntAct=EBI-4429217, EBI-541115;
CC Q8VZS3; Q9XGN1: TTG1; NbExp=3; IntAct=EBI-4429217, EBI-395803;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:27016098}.
CC -!- INDUCTION: Induced under phosphate deprivation conditions.
CC {ECO:0000269|PubMed:27016098}.
CC -!- DISRUPTION PHENOTYPE: Reduced number and length of lateral roots.
CC {ECO:0000269|PubMed:27016098}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD49976.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAM65539.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC008075; AAD49976.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE34826.1; -; Genomic_DNA.
DR EMBL; AY063886; AAL36242.1; -; mRNA.
DR EMBL; AY091241; AAM14180.1; -; mRNA.
DR EMBL; AY087993; AAM65539.1; ALT_INIT; mRNA.
DR PIR; C96711; C96711.
DR RefSeq; NP_564938.1; NM_105539.4.
DR AlphaFoldDB; Q8VZS3; -.
DR SMR; Q8VZS3; -.
DR IntAct; Q8VZS3; 23.
DR STRING; 3702.AT1G68670.1; -.
DR iPTMnet; Q8VZS3; -.
DR PaxDb; Q8VZS3; -.
DR PRIDE; Q8VZS3; -.
DR ProteomicsDB; 230319; -.
DR EnsemblPlants; AT1G68670.1; AT1G68670.1; AT1G68670.
DR GeneID; 843197; -.
DR Gramene; AT1G68670.1; AT1G68670.1; AT1G68670.
DR KEGG; ath:AT1G68670; -.
DR Araport; AT1G68670; -.
DR TAIR; locus:2026863; AT1G68670.
DR eggNOG; ENOG502QSXV; Eukaryota.
DR HOGENOM; CLU_036551_0_0_1; -.
DR InParanoid; Q8VZS3; -.
DR OMA; KMRRCHE; -.
DR OrthoDB; 907731at2759; -.
DR PhylomeDB; Q8VZS3; -.
DR PRO; PR:Q8VZS3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8VZS3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0001217; F:DNA-binding transcription repressor activity; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0055062; P:phosphate ion homeostasis; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044787; HRS1-like.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR PANTHER; PTHR31003; PTHR31003; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..354
FT /note="Transcription factor HHO2"
FT /id="PRO_0000439545"
FT DOMAIN 212..272
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 243..268
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 93..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 39424 MW; F5B3385509596D82 CRC64;
MMVEMDYAKK MQKCHEYVEA LEEEQKKIQV FQRELPLCLE LVTQAIEACR KELSGTTTTT
SEQCSEQTTS VCGGPVFEEF IPIKKISSLC EEVQEEEEED GEHESSPELV NNKKSDWLRS
VQLWNHSPDL NPKEERVAKK AKVVEVKPKS GAFQPFQKRV LETDLQPAVK VASSMPATTT
SSTTETCGGK SDLIKAGDEE RRIEQQQSQS HTHRKQRRCW SPELHRRFLN ALQQLGGSHV
ATPKQIRDHM KVDGLTNDEV KSHLQKYRLH TRRPAATSVA AQSTGNQQQP QFVVVGGIWV
PSSQDFPPPS DVANKGGVYA PVAVAQSPKR SLERSCNSPA ASSSTNTNTS TPVS
