HHO5_ARATH
ID HHO5_ARATH Reviewed; 363 AA.
AC F4JRB0; B9DF77; O23168; P92984; Q08A94; Q94BW2;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Transcription factor HHO5 {ECO:0000305};
DE AltName: Full=MYB-domain transcription factor HHO5 {ECO:0000305};
DE AltName: Full=Protein HRS1 HOMOLOG 5 {ECO:0000305};
DE AltName: Full=Protein ULT1 INTERACTING FACTOR 1 {ECO:0000303|PubMed:26903506};
GN Name=HHO5 {ECO:0000305}; Synonyms=UIF1 {ECO:0000303|PubMed:26903506};
GN OrderedLocusNames=At4g37180 {ECO:0000312|Araport:AT4G37180};
GN ORFNames=C7A10.180 {ECO:0000312|EMBL:CAB16780.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8893552; DOI=10.1046/j.1365-313x.1996.10040761.x;
RA Xia G., Ramachandran S., Hong Y., Chan Y.-S., Simanis V., Chua N.-H.;
RT "Identification of plant cytoskeletal, cell cycle-related and polarity-
RT related proteins using Schizosaccharomyces pombe.";
RL Plant J. 10:761-769(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-350 (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [8]
RP FUNCTION, INTERACTION WITH ULT1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=26903506; DOI=10.1242/dev.127365;
RA Moreau F., Thevenon E., Blanvillain R., Lopez-Vidriero I.,
RA Franco-Zorrilla J.M., Dumas R., Parcy F., Morel P., Trehin C., Carles C.C.;
RT "The Myb-domain protein ULTRAPETALA1 INTERACTING FACTOR 1 controls floral
RT meristem activities in Arabidopsis.";
RL Development 143:1108-1119(2016).
CC -!- FUNCTION: Transcriptional repressor that functions with ULT1 in a
CC pathway which regulates floral meristem homeostasis and organ number in
CC the flower. Binds specifically to the DNA sequence motif 5'-GTAGATTCCT-
CC 3' of WUS promoter, and may be involved in direct regulation of WUS
CC expression. Binds specifically to the DNA sequence motif 5'-AAGAATCTTT-
CC 3' found in the promoters of AG and the NAC domain genes CUC1, CUC2 and
CC CUC3, and may be involved in direct regulation of these gene
CC expressions.
CC -!- SUBUNIT: Interacts with ULT1. {ECO:0000269|PubMed:26903506}.
CC -!- INTERACTION:
CC F4JRB0-2; Q9XEE6: At2g40140; NbExp=3; IntAct=EBI-15192423, EBI-15197095;
CC F4JRB0-2; O80748: B-box domain protein 26; NbExp=4; IntAct=EBI-15192423, EBI-15191535;
CC F4JRB0-2; P93007: ERF112; NbExp=3; IntAct=EBI-15192423, EBI-15191903;
CC F4JRB0-2; O82277: TCP10; NbExp=3; IntAct=EBI-15192423, EBI-3133327;
CC F4JRB0-2; Q93Z00: TCP14; NbExp=3; IntAct=EBI-15192423, EBI-4424563;
CC F4JRB0-2; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-15192423, EBI-15192325;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625,
CC ECO:0000269|PubMed:26903506}. Cytoplasm, cytosol
CC {ECO:0000269|PubMed:26903506}. Note=Localizes in cytosolic foci.
CC {ECO:0000269|PubMed:26903506}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4JRB0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4JRB0-2; Sequence=VSP_058886;
CC -!- TISSUE SPECIFICITY: Expressed in roots, inflorescence apex, floral
CC primordia, stamen primordia, carpel primordia and ovules.
CC {ECO:0000269|PubMed:26903506}.
CC -!- DISRUPTION PHENOTYPE: Increased number of sepals and petals in flowers.
CC Loss of organ boundary and identity, producing fused sepals, petaloid
CC stamens and branching stamens fused along the filament.
CC {ECO:0000269|PubMed:26903506}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB38775.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC Sequence=CAB16780.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80384.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; U62741; AAB38775.1; ALT_SEQ; mRNA.
DR EMBL; Z99707; CAB16780.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161590; CAB80384.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE86762.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE86763.1; -; Genomic_DNA.
DR EMBL; AK316664; BAH19394.1; -; mRNA.
DR EMBL; BT028985; ABI93894.1; -; mRNA.
DR EMBL; AY039841; AAK63945.1; -; mRNA.
DR PIR; C85439; C85439.
DR RefSeq; NP_568018.1; NM_119881.3. [F4JRB0-2]
DR RefSeq; NP_849513.1; NM_179182.2. [F4JRB0-1]
DR AlphaFoldDB; F4JRB0; -.
DR SMR; F4JRB0; -.
DR IntAct; F4JRB0; 38.
DR STRING; 3702.AT4G37180.2; -.
DR PaxDb; F4JRB0; -.
DR PRIDE; F4JRB0; -.
DR EnsemblPlants; AT4G37180.1; AT4G37180.1; AT4G37180. [F4JRB0-2]
DR EnsemblPlants; AT4G37180.2; AT4G37180.2; AT4G37180. [F4JRB0-1]
DR GeneID; 829872; -.
DR Gramene; AT4G37180.1; AT4G37180.1; AT4G37180. [F4JRB0-2]
DR Gramene; AT4G37180.2; AT4G37180.2; AT4G37180. [F4JRB0-1]
DR KEGG; ath:AT4G37180; -.
DR Araport; AT4G37180; -.
DR TAIR; locus:2115070; AT4G37180.
DR eggNOG; ENOG502R6EG; Eukaryota.
DR InParanoid; F4JRB0; -.
DR OMA; NKEEDRC; -.
DR OrthoDB; 1260161at2759; -.
DR PRO; PR:F4JRB0; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JRB0; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:TAIR.
DR GO; GO:0048449; P:floral organ formation; IMP:TAIR.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0090701; P:specification of plant organ identity; IMP:TAIR.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044787; HRS1-like.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR006447; Myb_dom_plants.
DR PANTHER; PTHR31003; PTHR31003; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR TIGRFAMs; TIGR01557; myb_SHAQKYF; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; DNA-binding; Flowering; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..363
FT /note="Transcription factor HHO5"
FT /id="PRO_0000439547"
FT DOMAIN 214..274
FT /note="HTH myb-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 245..270
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 196..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 76..82
FT /note="Missing (in isoform 2)"
FT /id="VSP_058886"
FT CONFLICT 331
FT /note="E -> D (in Ref. 5; BAH19394)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 363 AA; 41679 MW; 450240FEF3551873 CRC64;
MVQTETDQRM GLNLNLSIYS LPKPLSQFLD EVSRIKDNHS KLSEIDGYVG KLEEERNKID
VFKRELPLCM LLLNEEIVFL CVAIGALKDE ARKGLSLMAS NGKFDDVERA KPETDKKSWM
SSAQLWISNP NSQFRSTNEE EEDRCVSQNP FQTCNYPNQG GVFMPFNRPP PPPPPAPLSL
MTPTSEMMMD YSRIEQSHHH HQFNKPSSQS HHIQKKEQRR RWSQELHRKF VDALHRLGGP
QVATPKQIRD LMKVDGLTND EVKSHLQKYR MHIRKHPLHP TKTLSSSDQP GVLERESQSL
ISLSRSDSPQ SPLVARGLFS SNVGHSSEED EEEEDEEEEK SDGRSSCRND ETKKKRQVLD
LEL
