HHP3_ARATH
ID HHP3_ARATH Reviewed; 344 AA.
AC Q9ZUH8; Q94K90; Q9C5R3;
DT 03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Heptahelical transmembrane protein 3;
DE AltName: Full=PAQR family protein HHP3;
GN Name=HHP3; OrderedLocusNames=At2g24150; ORFNames=F27D4.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=16263907; DOI=10.1093/jxb/eri311;
RA Hsieh M.H., Goodman H.M.;
RT "A novel gene family in Arabidopsis encoding putative heptahelical
RT transmembrane proteins homologous to human adiponectin receptors and
RT progestin receptors.";
RL J. Exp. Bot. 56:3137-3147(2005).
CC -!- FUNCTION: May play a role in abiotic stress response. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots and flowers.
CC {ECO:0000269|PubMed:16263907}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AC005967; AAD03376.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC07534.1; -; Genomic_DNA.
DR EMBL; AF325070; AAK17138.1; -; mRNA.
DR EMBL; AF370179; AAK43994.1; -; mRNA.
DR EMBL; BT001975; AAN71974.1; -; mRNA.
DR PIR; B84633; B84633.
DR RefSeq; NP_565564.1; NM_127976.5.
DR AlphaFoldDB; Q9ZUH8; -.
DR SMR; Q9ZUH8; -.
DR STRING; 3702.AT2G24150.1; -.
DR PaxDb; Q9ZUH8; -.
DR PRIDE; Q9ZUH8; -.
DR ProteomicsDB; 228801; -.
DR EnsemblPlants; AT2G24150.1; AT2G24150.1; AT2G24150.
DR GeneID; 816949; -.
DR Gramene; AT2G24150.1; AT2G24150.1; AT2G24150.
DR KEGG; ath:AT2G24150; -.
DR Araport; AT2G24150; -.
DR TAIR; locus:2047550; AT2G24150.
DR eggNOG; KOG0748; Eukaryota.
DR HOGENOM; CLU_023075_4_0_1; -.
DR InParanoid; Q9ZUH8; -.
DR OMA; EVPSWYA; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q9ZUH8; -.
DR PRO; PR:Q9ZUH8; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUH8; baseline and differential.
DR Genevisible; Q9ZUH8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0009725; P:response to hormone; IEP:TAIR.
DR GO; GO:0006979; P:response to oxidative stress; IMP:TAIR.
DR GO; GO:0009744; P:response to sucrose; IEP:TAIR.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Stress response; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..344
FT /note="Heptahelical transmembrane protein 3"
FT /id="PRO_0000430049"
FT TOPO_DOM 1..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 206..210
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 344 AA; 38853 MW; 0F51651D9C9EA9C7 CRC64;
MKRRRSAKKS PAMVTVTDWK GLDCGEETRI VRRLMKFEDL PEYLKDNEFI HNHYRCQWSL
KDTFLSAFSW HNETLNIWTH LIGFGIFLWM TVVSCLETTE ISLAGVFNGM AGVRICLSSN
QTLLHDSNVT HHISCLTSQG EAIPKWPWLV YLVGAMGCLI CSSVSHLLAC HSKRFNVFFW
RLDYAGISLM IVASFFAPIY YAFSCHPNFR LLYLSSISIL GLLAIITLLS PALSTPRFRP
FRANLFLAMG SSAVIPATHV LCLYWDHPNV FIALGYEIAT ALSYFVGATF YVSRVPERWK
PGAFDMAGHS HQIFHVFVVM GALAHCVTTL LIIDFSRASP SCGF
