HIBC3_ARATH
ID HIBC3_ARATH Reviewed; 378 AA.
AC Q6NMB0; O49331;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Probable 3-hydroxyisobutyryl-CoA hydrolase 3;
DE EC=3.1.2.4;
GN OrderedLocusNames=At2g30660; ORFNames=T11J7.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=11404361; DOI=10.1074/jbc.m104679200;
RA Zolman B.K., Monroe-Augustus M., Thompson B., Hawes J.W., Krukenberg K.A.,
RA Matsuda S.P., Bartel B.;
RT "chy1, an Arabidopsis mutant with impaired beta-oxidation, is defective in
RT a peroxisomal beta-hydroxyisobutyryl-CoA hydrolase.";
RL J. Biol. Chem. 276:31037-31046(2001).
CC -!- FUNCTION: Involved in valine catabolism. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC02737.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002340; AAC02737.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08424.1; -; Genomic_DNA.
DR EMBL; BT011751; AAS49114.1; -; mRNA.
DR EMBL; AK229794; BAF01625.1; -; mRNA.
DR PIR; B84711; B84711.
DR RefSeq; NP_180624.2; NM_128618.4.
DR AlphaFoldDB; Q6NMB0; -.
DR SMR; Q6NMB0; -.
DR STRING; 3702.AT2G30660.1; -.
DR PaxDb; Q6NMB0; -.
DR PRIDE; Q6NMB0; -.
DR ProteomicsDB; 230322; -.
DR EnsemblPlants; AT2G30660.1; AT2G30660.1; AT2G30660.
DR GeneID; 817616; -.
DR Gramene; AT2G30660.1; AT2G30660.1; AT2G30660.
DR KEGG; ath:AT2G30660; -.
DR Araport; AT2G30660; -.
DR TAIR; locus:2054437; AT2G30660.
DR eggNOG; ENOG502RY3N; Eukaryota.
DR HOGENOM; CLU_009834_22_1_1; -.
DR InParanoid; Q6NMB0; -.
DR OMA; IPQHPLE; -.
DR OrthoDB; 1369862at2759; -.
DR PhylomeDB; Q6NMB0; -.
DR BioCyc; ARA:AT2G30660-MON; -.
DR UniPathway; UPA00362; -.
DR PRO; PR:Q6NMB0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q6NMB0; baseline and differential.
DR Genevisible; Q6NMB0; AT.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IBA:GO_Central.
DR GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176; PTHR43176; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; SSF52096; 1.
PE 2: Evidence at transcript level;
KW Branched-chain amino acid catabolism; Hydrolase; Peroxisome;
KW Reference proteome.
FT CHAIN 1..378
FT /note="Probable 3-hydroxyisobutyryl-CoA hydrolase 3"
FT /id="PRO_0000392979"
FT BINDING 138
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 146
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 378 AA; 42567 MW; B367E4D1D57A8064 CRC64;
MASQSQVLVE EKSSVRILTL NRPKQLNALC FNMISRLLQL FRAYEEDPSV KLVILKGQGR
AFCAGGDVPP VVQNMVQGKW RLGADFFRDQ YTLNYVMATY SKPQVSILNG IVMGAGAGVS
IHGRFRIATE NTVFAMPETS LGLFPDVGAS YFLSRLPGFF GEYVGLTGAR LDGAELLACG
LATHFVPSTR LTALETDLCK VGSSDPSFVS TILDAYTQHP HLKQKSAYHR LDVIDRCFSK
RTMEEIISAL ERETTQELDD WSLTTIRALK KSSPSSLKIS LRSIREGRLQ GVGHCLTREY
RMVCHVMKGD LSKDLVEGCR AILIDKDRNP KWEPRRLEDM KDSMVDQFFE RVEEEERWED
LKLSPRNNLH ALRIAAKL
