HIBC5_ARATH
ID HIBC5_ARATH Reviewed; 409 AA.
AC Q8RXN4; Q9SZ48;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase-like protein 2, mitochondrial;
DE EC=3.1.2.-;
DE Flags: Precursor;
GN OrderedLocusNames=At4g31810; ORFNames=F11C18.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=11404361; DOI=10.1074/jbc.m104679200;
RA Zolman B.K., Monroe-Augustus M., Thompson B., Hawes J.W., Krukenberg K.A.,
RA Matsuda S.P., Bartel B.;
RT "chy1, an Arabidopsis mutant with impaired beta-oxidation, is defective in
RT a peroxisomal beta-hydroxyisobutyryl-CoA hydrolase.";
RL J. Biol. Chem. 276:31037-31046(2001).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND CLEAVAGE OF TRANSIT PEPTIDE AFTER
RP PHE-26.
RX PubMed=25732537; DOI=10.1093/jxb/erv064;
RA Carrie C., Venne A.S., Zahedi R.P., Soll J.;
RT "Identification of cleavage sites and substrate proteins for two
RT mitochondrial intermediate peptidases in Arabidopsis thaliana.";
RL J. Exp. Bot. 66:2691-2708(2015).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:25732537}.
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB40751.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB79899.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL049607; CAB40751.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161579; CAB79899.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE85963.1; -; Genomic_DNA.
DR EMBL; AY080787; AAL87270.1; -; mRNA.
DR EMBL; AY114019; AAM45067.1; -; mRNA.
DR PIR; T06303; T06303.
DR RefSeq; NP_194909.2; NM_119331.6.
DR PDB; 6XYW; EM; 3.86 A; BE=1-409.
DR PDBsum; 6XYW; -.
DR AlphaFoldDB; Q8RXN4; -.
DR SMR; Q8RXN4; -.
DR IntAct; Q8RXN4; 1.
DR STRING; 3702.AT4G31810.1; -.
DR iPTMnet; Q8RXN4; -.
DR PaxDb; Q8RXN4; -.
DR PRIDE; Q8RXN4; -.
DR ProteomicsDB; 230332; -.
DR EnsemblPlants; AT4G31810.1; AT4G31810.1; AT4G31810.
DR GeneID; 829310; -.
DR Gramene; AT4G31810.1; AT4G31810.1; AT4G31810.
DR KEGG; ath:AT4G31810; -.
DR Araport; AT4G31810; -.
DR TAIR; locus:2116797; AT4G31810.
DR eggNOG; KOG1684; Eukaryota.
DR HOGENOM; CLU_009834_22_1_1; -.
DR InParanoid; Q8RXN4; -.
DR OMA; CSGADMV; -.
DR OrthoDB; 1369862at2759; -.
DR PhylomeDB; Q8RXN4; -.
DR BioCyc; ARA:AT4G31810-MON; -.
DR PRO; PR:Q8RXN4; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8RXN4; baseline and differential.
DR Genevisible; Q8RXN4; AT.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IBA:GO_Central.
DR GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176; PTHR43176; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; SSF52096; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Hydrolase; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..26
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:25732537"
FT CHAIN 27..409
FT /note="3-hydroxyisobutyryl-CoA hydrolase-like protein 2,
FT mitochondrial"
FT /id="PRO_0000392981"
FT REGION 388..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 409 AA; 45500 MW; BCE4E782BE1C4570 CRC64;
MQTVKALRRV SEPLQWVRSV SYGRRFSALP NYSASDADFE DQVLVEGKAK SRAAILNNPS
SLNALSAPMV GRLKRLYESW EENPAISFVL MKGSGKTFCS GADVLSLYHS INEGNTEESK
LFFENLYKFV YLQGTYLKPN IAIMDGVTMG CGGGISLPGM FRVATDKTVL AHPEVQIGFH
PDAGASYYLS RLPGYLGEYL ALTGQKLNGV EMIACGLATH YCLNARLPLI EERIGKLLTD
DPAVIEDSLA QYGDLVYPDS SSVLHKIELI DKYFGLDTVE EIIEAMENEA ANSCNEWCKK
TLKQIKEASP LSLKITLQSI REGRFQTLDQ CLTHEYRISI CGVSKVVSGD FCEGIRARLV
DKDFAPKWDP PRLEDVSKDM VDCYFTPASE LDDSDSELKL PTAQREPYF
