HIBC7_ARATH
ID HIBC7_ARATH Reviewed; 418 AA.
AC Q9LK08; A8MS00;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase-like protein 4, mitochondrial;
DE EC=3.1.2.-;
DE Flags: Precursor;
GN OrderedLocusNames=At3g24360; ORFNames=K7M2.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=11404361; DOI=10.1074/jbc.m104679200;
RA Zolman B.K., Monroe-Augustus M., Thompson B., Hawes J.W., Krukenberg K.A.,
RA Matsuda S.P., Bartel B.;
RT "chy1, an Arabidopsis mutant with impaired beta-oxidation, is defective in
RT a peroxisomal beta-hydroxyisobutyryl-CoA hydrolase.";
RL J. Biol. Chem. 276:31037-31046(2001).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LK08-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LK08-2; Sequence=VSP_038867;
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000305}.
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DR EMBL; AP000382; BAB02936.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76894.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76895.1; -; Genomic_DNA.
DR EMBL; BX823664; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001078205.1; NM_001084736.2. [Q9LK08-2]
DR RefSeq; NP_189079.2; NM_113343.3. [Q9LK08-1]
DR AlphaFoldDB; Q9LK08; -.
DR SMR; Q9LK08; -.
DR STRING; 3702.AT3G24360.1; -.
DR PaxDb; Q9LK08; -.
DR PRIDE; Q9LK08; -.
DR ProteomicsDB; 230340; -. [Q9LK08-1]
DR EnsemblPlants; AT3G24360.1; AT3G24360.1; AT3G24360. [Q9LK08-1]
DR EnsemblPlants; AT3G24360.2; AT3G24360.2; AT3G24360. [Q9LK08-2]
DR GeneID; 822025; -.
DR Gramene; AT3G24360.1; AT3G24360.1; AT3G24360. [Q9LK08-1]
DR Gramene; AT3G24360.2; AT3G24360.2; AT3G24360. [Q9LK08-2]
DR KEGG; ath:AT3G24360; -.
DR Araport; AT3G24360; -.
DR TAIR; locus:2087218; AT3G24360.
DR eggNOG; KOG1684; Eukaryota.
DR InParanoid; Q9LK08; -.
DR OMA; KQLYMYI; -.
DR OrthoDB; 1369862at2759; -.
DR PhylomeDB; Q9LK08; -.
DR BioCyc; ARA:AT3G24360-MON; -.
DR PRO; PR:Q9LK08; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LK08; baseline and differential.
DR Genevisible; Q9LK08; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IBA:GO_Central.
DR GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176; PTHR43176; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; SSF52096; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Hydrolase; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..39
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 40..418
FT /note="3-hydroxyisobutyryl-CoA hydrolase-like protein 4,
FT mitochondrial"
FT /id="PRO_0000392983"
FT VAR_SEQ 108..128
FT /note="MDIKGVVAEILMDKNTSLVQK -> GDVKQITSKNQLSDMIE (in
FT isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_038867"
FT CONFLICT 27
FT /note="K -> E (in Ref. 3; BX823664)"
FT /evidence="ECO:0000305"
FT CONFLICT 35
FT /note="K -> R (in Ref. 3; BX823664)"
FT /evidence="ECO:0000305"
FT CONFLICT 48
FT /note="K -> R (in Ref. 3; BX823664)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="N -> D (in Ref. 3; BX823664)"
FT /evidence="ECO:0000305"
FT CONFLICT 131
FT /note="T -> A (in Ref. 3; BX823664)"
FT /evidence="ECO:0000305"
FT CONFLICT 326
FT /note="F -> L (in Ref. 3; BX823664)"
FT /evidence="ECO:0000305"
FT CONFLICT 342
FT /note="K -> T (in Ref. 3; BX823664)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 418 AA; 45740 MW; 1DDCCD26C0D62F4D CRC64;
MIKSLSLASA RIFFSRTSPS FLIPFSKLSV SHRRKFSVMA SGSDEFVKGN VYPNGVALIT
LDRPKALNAM NLEMDLKYKS LLDEWEYDPG VKCVVVEGST SRAFCAGMDI KGVVAEILMD
KNTSLVQKVF TAEYSLICKI AGYRKPYISL MDGITMGFGL GLSGHGRYRV ITERTVLAMP
ENGIGLFPDV GFSYIAAHSP GEGSVGAYLG MTGRRISTPS DALFVGLGTH YVPSGKLGSL
REAILSADLS KDPQQHIQAT LSNYSSDPET ESHLQMLLPQ IESAFSVSKS VKETIEELKK
FQQSSEASVA EWANEAVQGI EKGAPFSLYL THKYFSKVAC AKGKTNNAMA TLNGVMITEY
RIALRSALRS DFTEGVRAVL TDKDQNPKWK PASLDEVDET EVDALFMPLS PEFEELNV
