ID   HIBCH_XENTR             Reviewed;         385 AA.
AC   Q28FR6; A9ULB0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial;
DE            EC=3.1.2.4;
DE   AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase;
DE            Short=HIB-CoA hydrolase;
DE            Short=HIBYL-CoA-H;
DE   Flags: Precursor;
GN   Name=hibch; ORFNames=TGas039e14.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline
CC       catabolite. Has high activity toward isobutyryl-CoA. Could be an
CC       isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also
CC       hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC         methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC         ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC   -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; CR761811; CAJ81517.1; -; mRNA.
DR   EMBL; BC157188; AAI57189.1; -; mRNA.
DR   RefSeq; NP_001016188.1; NM_001016188.2.
DR   AlphaFoldDB; Q28FR6; -.
DR   SMR; Q28FR6; -.
DR   STRING; 8364.ENSXETP00000033364; -.
DR   PaxDb; Q28FR6; -.
DR   Ensembl; ENSXETT00000033364; ENSXETP00000033364; ENSXETG00000015247.
DR   GeneID; 548942; -.
DR   KEGG; xtr:548942; -.
DR   CTD; 26275; -.
DR   Xenbase; XB-GENE-947696; hibch.
DR   eggNOG; KOG1684; Eukaryota.
DR   HOGENOM; CLU_009834_22_1_1; -.
DR   InParanoid; Q28FR6; -.
DR   OMA; AYRNNEH; -.
DR   OrthoDB; 1369862at2759; -.
DR   PhylomeDB; Q28FR6; -.
DR   TreeFam; TF314329; -.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015247; Expressed in skeletal muscle tissue and 14 other tissues.
DR   ExpressionAtlas; Q28FR6; differential.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IBA:GO_Central.
DR   GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR045004; ECH_dom.
DR   InterPro; IPR032259; HIBYL-CoA-H.
DR   PANTHER; PTHR43176; PTHR43176; 1.
DR   Pfam; PF16113; ECH_2; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   2: Evidence at transcript level;
KW   Branched-chain amino acid catabolism; Hydrolase; Mitochondrion;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..385
FT                   /note="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"
FT                   /id="PRO_0000284934"
FT   BINDING         120
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         145
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         168
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         176
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   385 AA;  42336 MW;  E6F215988E93D686 CRC64;
     MSLGLLESQL RLKVFGRLQV IRQHLRMTNH TVKDGECLLT KAGCAGVITL NRPKALNALN
     LGMIRLIYPQ LGLWEEDPET YLVIIKGVGG KAFCAGGDIR AVTDAGKAGD RLAQDFFREE
     YILNNAIGTY KKPYVALIDG ITMGGGVGLS VHGHFRVASE NTLFAMPETA IGLFPDVGGG
     YFLPRLPGKL GLYLALTGFR LKGSDVQKAG IATHFVESEK IPSLEQDLVA MKCPSKENVA
     DVLDSYHNKS YAAQDKPFVL AEHLDKINSL FSASSVEAII ENLRCDGSSF ALKQLQTLST
     MSPTSLKITF RQLKEGSSMS LQEVLTMEYR LSQACMKGYD FYEGVRAVLI DKNQNAKWNP
     ELLEEVTDDY IDSYFTSLGN SDLKL