ID   HIBN_XENLA              Reviewed;         590 AA.
AC   P06180;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Histone-binding protein N1/N2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Oocyte;
RX   PubMed=3549279; DOI=10.1002/j.1460-2075.1986.tb04681.x;
RA   Kleinschmidt J.A., Dingwall C., Maier G., Franke W.W.;
RT   "Molecular characterization of a karyophilic, histone-binding protein: cDNA
RT   cloning, amino acid sequence and expression of nuclear protein N1/N2 of
RT   Xenopus laevis.";
RL   EMBO J. 5:3547-3552(1986).
CC   -!- FUNCTION: This protein is involved in nucleosome assembly. It is bound
CC       to H3 and H4 in the absence of DNA, but released from H3 and H4 in the
CC       presence of DNA.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the NASP family. {ECO:0000305}.
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DR   EMBL; X04712; CAA28419.1; -; mRNA.
DR   PIR; A25680; A25680.
DR   RefSeq; NP_001081537.1; NM_001088068.1.
DR   PDB; 1PJN; X-ray; 2.50 A; A=532-552.
DR   PDBsum; 1PJN; -.
DR   AlphaFoldDB; P06180; -.
DR   SMR; P06180; -.
DR   DNASU; 397901; -.
DR   GeneID; 397901; -.
DR   KEGG; xla:397901; -.
DR   CTD; 397901; -.
DR   Xenbase; XB-GENE-980259; nasp.S.
DR   OrthoDB; 1176629at2759; -.
DR   EvolutionaryTrace; P06180; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 397901; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0061676; F:importin-alpha family protein binding; IPI:CAFA.
DR   Gene3D; 1.25.40.10; -; 1.
DR   IDEAL; IID50002; -.
DR   InterPro; IPR019544; Tetratricopeptide_SHNi-TPR_dom.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF10516; SHNi-TPR; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 3.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Nucleus; Reference proteome;
KW   Repeat; TPR repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..590
FT                   /note="Histone-binding protein N1/N2"
FT                   /id="PRO_0000083971"
FT   REPEAT          36..69
FT                   /note="TPR 1"
FT   REPEAT          357..390
FT                   /note="TPR 2"
FT   REPEAT          399..432
FT                   /note="TPR 3"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           531..537
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        105..119
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..251
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..325
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        528..553
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   590 AA;  65029 MW;  C4F072577665E180 CRC64;
     MAEETAALST EKTEDTSTAP STSAEKADGI DIDTEAKRLM GAGQKHLVMK DVRSAVNLFQ
     EASSLLAKQY GETADECAEA FYSYGMSLLE LARLENGVLG NALEGMPEDD EEEAEKEEDP
     NIPSADNLDE KEREQLREQV YDAMAEDQRA PDDTSESEAK GKPEGDSKDK EADEKMKNGQ
     KETEKVTDDL KIDSASRDVP MDKSGKGEPP ESKDAETLVE QKESKPETLK EKSIETKEKD
     LSKEKTDAKE TANQSPDSTE VAEEKMDSEA SESKESTSIP PTENEANKPD DPEKMEEEEE
     GEDSEENEDG TEENEGTEEK ETEEEDVGNL QLAWEMLDLC KTIFKRQQSK EAQLKAAQAH
     QKLGEVCIES ENYSQAVEDF LACLNIQKEH LEEHDRLLAE THYHLGLAYQ YSSKHEEAIS
     HFTQSIGVIE KRMDVLTKQL EASVGELVDE VKKEMDELKD LLPDIKEKIE DSKEAQKNAT
     VTEKALKETL VGGSSGFSKE NGSTSSSSAV EKSGDSTVPV TNCVSDISHL VRKKRKTEEE
     SPLKDKDAKK SKQEPVANGA GNGDAVVPTN EEAEKAEEAS METATVESTA