ID   HICA2_PHOLL             Reviewed;          58 AA.
AC   Q7MZD9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 2.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Probable mRNA interferase HicA 2;
DE            EC=3.1.-.-;
DE   AltName: Full=Endoribonuclease HicA 2;
DE   AltName: Full=Toxin HicA 2;
GN   Name=hicA2; OrderedLocusNames=plu4353;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. A
CC       probable translation-independent mRNA interferase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Probably forms a complex with the cognate antitoxin HicB 2
CC       which inhibits the mRNA interferase activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HicA mRNA interferase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE16725.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BX571873; CAE16725.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041381194.1; NC_005126.1.
DR   AlphaFoldDB; Q7MZD9; -.
DR   SMR; Q7MZD9; -.
DR   EnsemblBacteria; CAE16725; CAE16725; plu4353.
DR   GeneID; 24169238; -.
DR   KEGG; plu:plu4353; -.
DR   eggNOG; COG1724; Bacteria.
DR   HOGENOM; CLU_164851_5_0_6; -.
DR   OrthoDB; 2053618at2; -.
DR   BioCyc; PLUM243265:PLU_RS21495-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   Gene3D; 3.30.920.30; -; 1.
DR   InterPro; IPR012933; HicA_mRNA_interferase.
DR   InterPro; IPR038570; HicA_sf.
DR   Pfam; PF07927; HicA_toxin; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding;
KW   Stress response; Toxin-antitoxin system.
FT   CHAIN           1..58
FT                   /note="Probable mRNA interferase HicA 2"
FT                   /id="PRO_0000259910"
SQ   SEQUENCE   58 AA;  6784 MW;  ADA9D8BEDD23B022 CRC64;
     MKQSEFRRWL KAQGAEFKDG TNHLKVFLNG KQTTMPRHPS KEIPEPLRKL ILKQPGIK