ID   HICA_ECO57              Reviewed;          58 AA.
AC   P0CJ67;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Probable mRNA interferase HicA;
DE            EC=3.1.-.-;
DE   AltName: Full=Endoribonuclease HicA;
DE   AltName: Full=Toxin HicA;
GN   Name=hicA; OrderedLocusNames=Z2280.1, ECs2041.1;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. A
CC       probable translation-independent mRNA interferase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Probably forms a complex with the antitoxin HicB which
CC       inhibits the mRNA interferase activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HicA mRNA interferase family. {ECO:0000305}.
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DR   EMBL; AE005174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BA000007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_000813794.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0CJ67; -.
DR   SMR; P0CJ67; -.
DR   STRING; 155864.EDL933_2213; -.
DR   GeneID; 66674712; -.
DR   PATRIC; fig|83334.175.peg.2618; -.
DR   eggNOG; COG1724; Bacteria.
DR   OMA; KRSIMPR; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   Gene3D; 3.30.920.30; -; 1.
DR   InterPro; IPR012933; HicA_mRNA_interferase.
DR   InterPro; IPR038570; HicA_sf.
DR   Pfam; PF07927; HicA_toxin; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; Reference proteome; RNA-binding;
KW   Stress response; Toxin-antitoxin system.
FT   CHAIN           1..58
FT                   /note="Probable mRNA interferase HicA"
FT                   /id="PRO_0000404519"
SQ   SEQUENCE   58 AA;  6782 MW;  C5656B478837BAB6 CRC64;
     MKQSEFRRWL ESQGVDVANG SNHLKLRFHG RRSVMPRHPC DEIKEPLRKA ILKQLGLS