ID   HICA_PSEPF              Reviewed;          60 AA.
AC   Q3KJK8;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Probable mRNA interferase HicA;
DE            EC=3.1.-.-;
DE   AltName: Full=Endoribonuclease HicA;
DE   AltName: Full=Toxin HicA;
GN   Name=hicA; OrderedLocusNames=Pfl01_0304;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system. A
CC       probable translation-independent mRNA interferase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Probably forms a complex with the antitoxin HicB 1 which
CC       inhibits the mRNA interferase activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HicA mRNA interferase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABA72048.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000094; ABA72048.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041475489.1; NC_007492.2.
DR   AlphaFoldDB; Q3KJK8; -.
DR   SMR; Q3KJK8; -.
DR   STRING; 205922.Pfl01_0304; -.
DR   EnsemblBacteria; ABA72048; ABA72048; Pfl01_0304.
DR   KEGG; pfo:Pfl01_0304; -.
DR   eggNOG; COG1724; Bacteria.
DR   HOGENOM; CLU_164851_5_0_6; -.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003729; F:mRNA binding; IEA:InterPro.
DR   Gene3D; 3.30.920.30; -; 1.
DR   InterPro; IPR012933; HicA_mRNA_interferase.
DR   InterPro; IPR038570; HicA_sf.
DR   Pfam; PF07927; HicA_toxin; 1.
PE   3: Inferred from homology;
KW   Endonuclease; Hydrolase; Nuclease; RNA-binding; Stress response;
KW   Toxin-antitoxin system.
FT   CHAIN           1..60
FT                   /note="Probable mRNA interferase HicA"
FT                   /id="PRO_0000259911"
SQ   SEQUENCE   60 AA;  6769 MW;  B0444E2693567941 CRC64;
     MKYSEFRRWL KAQGVEFQTG KGSHFKVSLN GKSTVFPDHG AKEMGEGLRK SIVKQLGLKD