ID   HICB1_PHOLL             Reviewed;         155 AA.
AC   Q7N1I3;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Antitoxin HicB 1;
GN   Name=hicB1; OrderedLocusNames=plu3491;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Functions as an mRNA interferase antitoxin preventing effects of the
CC       HicA 1 toxin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probably forms a complex with the probable mRNA interferase
CC       HicA1 (its cognate toxin); when complexed with HicA 1 inhibits the
CC       toxin activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HicB antitoxin family. {ECO:0000305}.
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DR   EMBL; BX571870; CAE15864.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7N1I3; -.
DR   SMR; Q7N1I3; -.
DR   STRING; 243265.plu3491; -.
DR   EnsemblBacteria; CAE15864; CAE15864; plu3491.
DR   KEGG; plu:plu3491; -.
DR   eggNOG; COG1598; Bacteria.
DR   HOGENOM; CLU_140890_2_0_6; -.
DR   OMA; AFEFYFE; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR031807; HicB-like.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR035069; TTHA1013/TTHA0281-like.
DR   Pfam; PF15919; HicB_lk_antitox; 1.
DR   SUPFAM; SSF143100; SSF143100; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Stress response;
KW   Toxin-antitoxin system; Transcription; Transcription regulation.
FT   CHAIN           1..155
FT                   /note="Antitoxin HicB 1"
FT                   /id="PRO_0000404520"
FT   DOMAIN          99..153
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        110..129
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   155 AA;  17359 MW;  D3A0CC6023308AD4 CRC64;
     MIKTRLARGG FSHRFIIKNM RYPVTLEPVE EGGYFVSFPD IPEALTQGDT REEALEMALD
     ALITAFEFYF EDNEKIPLPG PVGQDYVDVP LSVASKVLML NAFLDSKLTQ IELANRMGVK
     KQEVTRIFDL RHSTKIDTVG KVASAIGHQL TLSIE