ID   HICB2_PHOLL             Reviewed;         139 AA.
AC   Q7MZD8;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Antitoxin HicB 2;
GN   Name=hicB2; OrderedLocusNames=plu4354;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Functions as an mRNA interferase antitoxin preventing effects of the
CC       HicA 2 toxin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probably forms a complex with the probable mRNA interferase
CC       HicA2 (its cognate toxin); when complexed with HicA inhibits the toxin
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HicB antitoxin family. {ECO:0000305}.
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DR   EMBL; BX571873; CAE16726.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q7MZD8; -.
DR   SMR; Q7MZD8; -.
DR   STRING; 243265.plu4354; -.
DR   EnsemblBacteria; CAE16726; CAE16726; plu4354.
DR   KEGG; plu:plu4354; -.
DR   eggNOG; COG1598; Bacteria.
DR   HOGENOM; CLU_140890_2_0_6; -.
DR   OMA; EIPEMHA; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR031807; HicB-like.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR035069; TTHA1013/TTHA0281-like.
DR   Pfam; PF15919; HicB_lk_antitox; 1.
DR   SUPFAM; SSF143100; SSF143100; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Stress response;
KW   Toxin-antitoxin system; Transcription; Transcription regulation.
FT   CHAIN           1..139
FT                   /note="Antitoxin HicB 2"
FT                   /id="PRO_0000404521"
FT   DOMAIN          87..137
FT                   /note="HTH cro/C1-type"
FT   DNA_BIND        96..113
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   139 AA;  15387 MW;  98DD626271593A6F CRC64;
     MSKNMRYPVK FEHDETGWAV MFPDIPEALT GGDTREEALA MAQDALVTAF DFYFEDRREI
     PTPSTKGEAF VEVPASIAAK VLLLNTMLQT RTSNAELARL LGTRPQEIQR IVSLSHSTKI
     DTIANALNAL GKHLELVAI