ID   HICB_ECO57              Reviewed;         138 AA.
AC   P67698; P76107;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Antitoxin HicB;
GN   Name=hicB; OrderedLocusNames=Z2281, ECs2042;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Functions as an mRNA interferase antitoxin preventing effects of the
CC       HicA toxin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probably forms a complex with the probable mRNA interferase
CC       HicA; when complexed with HicA inhibits the toxin activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HicB antitoxin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG56337.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAB35465.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE005174; AAG56337.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB35465.1; ALT_INIT; Genomic_DNA.
DR   PIR; B90884; B90884.
DR   RefSeq; NP_310069.2; NC_002695.1.
DR   RefSeq; WP_001270286.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P67698; -.
DR   SMR; P67698; -.
DR   STRING; 155864.EDL933_2212; -.
DR   EnsemblBacteria; AAG56337; AAG56337; Z2281.
DR   EnsemblBacteria; BAB35465; BAB35465; ECs_2042.
DR   GeneID; 66674711; -.
DR   GeneID; 917241; -.
DR   KEGG; ece:Z2281; -.
DR   KEGG; ecs:ECs_2042; -.
DR   PATRIC; fig|386585.9.peg.2142; -.
DR   eggNOG; COG1598; Bacteria.
DR   HOGENOM; CLU_140890_2_0_6; -.
DR   OMA; AFEFYFE; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR031807; HicB-like.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR035069; TTHA1013/TTHA0281-like.
DR   Pfam; PF15919; HicB_lk_antitox; 1.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF143100; SSF143100; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Stress response;
KW   Toxin-antitoxin system; Transcription; Transcription regulation.
FT   CHAIN           1..138
FT                   /note="Antitoxin HicB"
FT                   /id="PRO_0000149758"
FT   DOMAIN          82..136
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        93..112
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   138 AA;  15247 MW;  C7B6C1F0D0A8BE26 CRC64;
     MRYPVTLTPA PEGGYMVSFV DIPEALTQGE TVAEAMEAAK DALLTAFDFY FEDNELIPLP
     SPLNSHDHFI EVPLSVASKV LLLNAFLQSE ITQQELARRI GKPKQEITRL FNLHHATKID
     AVQLAAKALG KELSLVMV