ID   HICB_PSEPF              Reviewed;         146 AA.
AC   Q3KJK7;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Antitoxin HicB;
GN   Name=hicB; OrderedLocusNames=Pfl01_0305;
OS   Pseudomonas fluorescens (strain Pf0-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=205922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pf0-1;
RX   PubMed=19432983; DOI=10.1186/gb-2009-10-5-r51;
RA   Silby M.W., Cerdeno-Tarraga A.M., Vernikos G.S., Giddens S.R.,
RA   Jackson R.W., Preston G.M., Zhang X.-X., Moon C.D., Gehrig S.M.,
RA   Godfrey S.A.C., Knight C.G., Malone J.G., Robinson Z., Spiers A.J.,
RA   Harris S., Challis G.L., Yaxley A.M., Harris D., Seeger K., Murphy L.,
RA   Rutter S., Squares R., Quail M.A., Saunders E., Mavromatis K.,
RA   Brettin T.S., Bentley S.D., Hothersall J., Stephens E., Thomas C.M.,
RA   Parkhill J., Levy S.B., Rainey P.B., Thomson N.R.;
RT   "Genomic and genetic analyses of diversity and plant interactions of
RT   Pseudomonas fluorescens.";
RL   Genome Biol. 10:R51.1-R51.16(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Functions as an mRNA interferase antitoxin preventing effects of the
CC       HicA toxin (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Probably forms a complex with the probable mRNA interferase
CC       HicA; when complexed with HicA inhibits the toxin activity.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the HicB antitoxin family. {ECO:0000305}.
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DR   EMBL; CP000094; ABA72049.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q3KJK7; -.
DR   SMR; Q3KJK7; -.
DR   STRING; 205922.Pfl01_0305; -.
DR   EnsemblBacteria; ABA72049; ABA72049; Pfl01_0305.
DR   KEGG; pfo:Pfl01_0305; -.
DR   eggNOG; COG1598; Bacteria.
DR   HOGENOM; CLU_140890_1_1_6; -.
DR   OMA; EIPEMHA; -.
DR   Proteomes; UP000002704; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR035069; TTHA1013/TTHA0281-like.
DR   SUPFAM; SSF143100; SSF143100; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Stress response; Toxin-antitoxin system;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..146
FT                   /note="Antitoxin HicB"
FT                   /id="PRO_0000404522"
SQ   SEQUENCE   146 AA;  16017 MW;  60B0DC29C5A0FB6B CRC64;
     MRGSVMFEYA LEVHEEPGSV WLSCAEIPEM HAAGDTLEEA LDGAIDAMET ALSIYVDDRR
     LIPTGDAGEQ ESDAVLRLPA LTAAKVGLWN TLLESGVSKA ELARRLGVQR PQVDRLVDFL
     HHSKIENVER ALQQLGRRIL LSVEAA