HID1_HUMAN
ID HID1_HUMAN Reviewed; 788 AA.
AC Q8IV36; Q8N5L6; Q8TE83; Q9NT34;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein HID1;
DE AltName: Full=Down-regulated in multiple cancers 1;
DE AltName: Full=HID1 domain-containing protein;
DE AltName: Full=Protein hid-1 homolog;
GN Name=HID1; Synonyms=C17orf28, DMC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11281419; DOI=10.1007/s100380170115;
RA Harada H., Nagai H., Tsuneizumi M., Mikami I., Sugano S., Emi M.;
RT "Identification of DMC1, a novel gene in the TOC region on 17q25.1 that
RT shows loss of expression in multiple human cancers.";
RL J. Hum. Genet. 46:90-95(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-355 (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MYRISTOYLATION AT GLY-2.
RX PubMed=21337012; DOI=10.1007/s13238-011-1008-3;
RA Wang L., Zhan Y., Song E., Yu Y., Jiu Y., Du W., Lu J., Liu P., Xu P.,
RA Xu T.;
RT "HID-1 is a peripheral membrane protein primarily associated with the
RT medial- and trans- Golgi apparatus.";
RL Protein Cell 2:74-85(2011).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-653, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
CC -!- FUNCTION: May play an important role in the development of cancers in a
CC broad range of tissues. {ECO:0000269|PubMed:11281419}.
CC -!- INTERACTION:
CC Q8IV36; Q5SZQ8-2: CELF3; NbExp=3; IntAct=EBI-743438, EBI-12258670;
CC Q8IV36; P28329-3: CHAT; NbExp=3; IntAct=EBI-743438, EBI-25837549;
CC Q8IV36; O75534: CSDE1; NbExp=3; IntAct=EBI-743438, EBI-719186;
CC Q8IV36; O75534-3: CSDE1; NbExp=3; IntAct=EBI-743438, EBI-12397458;
CC Q8IV36; Q08426: EHHADH; NbExp=3; IntAct=EBI-743438, EBI-2339219;
CC Q8IV36; P22607: FGFR3; NbExp=3; IntAct=EBI-743438, EBI-348399;
CC Q8IV36; P01112: HRAS; NbExp=3; IntAct=EBI-743438, EBI-350145;
CC Q8IV36; O15357: INPPL1; NbExp=2; IntAct=EBI-743438, EBI-1384248;
CC Q8IV36; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-743438, EBI-5235340;
CC Q8IV36; Q86WV8: TSC1; NbExp=3; IntAct=EBI-743438, EBI-12806590;
CC Q8IV36; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-743438, EBI-607755;
CC Q8IV36; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-743438, EBI-741480;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21337012}. Golgi
CC apparatus membrane {ECO:0000269|PubMed:21337012}; Lipid-anchor
CC {ECO:0000269|PubMed:21337012}. Note=Shuttles between the cytosol and
CC the Golgi apparatus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IV36-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IV36-2; Sequence=VSP_014473;
CC Name=3;
CC IsoId=Q8IV36-3; Sequence=VSP_014472;
CC -!- TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, colon, spleen,
CC kidney, liver, small intestine and lung. Highest expression is seen in
CC brain and placenta. Loss of expression is seen in some breast,
CC cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer
CC lines. Highly expressed in secretory cell lines.
CC {ECO:0000269|PubMed:11281419, ECO:0000269|PubMed:21337012}.
CC -!- SIMILARITY: Belongs to the hid-1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85070.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK074401; BAB85070.1; ALT_FRAME; mRNA.
DR EMBL; BC032219; AAH32219.2; -; mRNA.
DR EMBL; BC035372; AAH35372.1; -; mRNA.
DR EMBL; AL137556; CAB70810.2; -; mRNA.
DR CCDS; CCDS32726.1; -. [Q8IV36-1]
DR PIR; T46395; T46395.
DR RefSeq; NP_085133.1; NM_030630.2. [Q8IV36-1]
DR RefSeq; XP_005257283.1; XM_005257226.1. [Q8IV36-2]
DR AlphaFoldDB; Q8IV36; -.
DR BioGRID; 129720; 21.
DR IntAct; Q8IV36; 23.
DR MINT; Q8IV36; -.
DR STRING; 9606.ENSP00000413520; -.
DR iPTMnet; Q8IV36; -.
DR PhosphoSitePlus; Q8IV36; -.
DR BioMuta; HID1; -.
DR DMDM; 68565199; -.
DR EPD; Q8IV36; -.
DR jPOST; Q8IV36; -.
DR MassIVE; Q8IV36; -.
DR MaxQB; Q8IV36; -.
DR PaxDb; Q8IV36; -.
DR PeptideAtlas; Q8IV36; -.
DR PRIDE; Q8IV36; -.
DR ProteomicsDB; 70652; -. [Q8IV36-1]
DR ProteomicsDB; 70653; -. [Q8IV36-2]
DR ProteomicsDB; 70654; -. [Q8IV36-3]
DR Antibodypedia; 19485; 254 antibodies from 24 providers.
DR DNASU; 283987; -.
DR Ensembl; ENST00000425042.7; ENSP00000413520.2; ENSG00000167861.16. [Q8IV36-1]
DR GeneID; 283987; -.
DR KEGG; hsa:283987; -.
DR MANE-Select; ENST00000425042.7; ENSP00000413520.2; NM_030630.3; NP_085133.1.
DR UCSC; uc002jmj.5; human. [Q8IV36-1]
DR CTD; 283987; -.
DR DisGeNET; 283987; -.
DR GeneCards; HID1; -.
DR HGNC; HGNC:15736; HID1.
DR HPA; ENSG00000167861; Tissue enhanced (pancreas, salivary gland).
DR MIM; 605752; gene.
DR neXtProt; NX_Q8IV36; -.
DR OpenTargets; ENSG00000167861; -.
DR PharmGKB; PA25583; -.
DR VEuPathDB; HostDB:ENSG00000167861; -.
DR eggNOG; KOG2226; Eukaryota.
DR GeneTree; ENSGT00390000003070; -.
DR HOGENOM; CLU_007392_1_0_1; -.
DR InParanoid; Q8IV36; -.
DR OMA; GTTAWFR; -.
DR OrthoDB; 319576at2759; -.
DR PhylomeDB; Q8IV36; -.
DR TreeFam; TF314291; -.
DR PathwayCommons; Q8IV36; -.
DR SignaLink; Q8IV36; -.
DR BioGRID-ORCS; 283987; 52 hits in 1072 CRISPR screens.
DR ChiTaRS; HID1; human.
DR GenomeRNAi; 283987; -.
DR Pharos; Q8IV36; Tdark.
DR PRO; PR:Q8IV36; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8IV36; protein.
DR Bgee; ENSG00000167861; Expressed in right hemisphere of cerebellum and 142 other tissues.
DR ExpressionAtlas; Q8IV36; baseline and differential.
DR Genevisible; Q8IV36; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0090498; C:extrinsic component of Golgi membrane; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0005797; C:Golgi medial cisterna; IDA:UniProtKB.
DR GO; GO:0000138; C:Golgi trans cisterna; IDA:UniProtKB.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR026705; Hid-1/Ecm30.
DR PANTHER; PTHR21575; PTHR21575; 1.
DR Pfam; PF12722; Hid1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Golgi apparatus; Lipoprotein; Membrane;
KW Myristate; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..788
FT /note="Protein HID1"
FT /id="PRO_0000079296"
FT REGION 297..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 653
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692"
FT MOD_RES 670
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R1F6"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:21337012"
FT VAR_SEQ 30..257
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014472"
FT VAR_SEQ 130
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_014473"
FT CONFLICT 352
FT /note="P -> L (in Ref. 4; CAB70810)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 788 AA; 88745 MW; 52BE7F0ACC9BE0E3 CRC64;
MGSTDSKLNF RKAVIQLTTK TQPVEATDDA FWDQFWADTA TSVQDVFALV PAAEIRAVRE
ESPSNLATLC YKAVEKLVQG AESGCHSEKE KQIVLNCSRL LTRVLPYIFE DPDWRGFFWS
TVPGAGRGGQ GEEDDEHARP LAESLLLAIA DLLFCPDFTV QSHRRSTVDS AEDVHSLDSC
EYIWEAGVGF AHSPQPNYIH DMNRMELLKL LLTCFSEAMY LPPAPESGST NPWVQFFCST
ENRHALPLFT SLLNTVCAYD PVGYGIPYNH LLFSDYREPL VEEAAQVLIV TLDHDSASSA
SPTVDGTTTG TAMDDADPPG PENLFVNYLS RIHREEDFQF ILKGIARLLS NPLLQTYLPN
STKKIQFHQE LLVLFWKLCD FNKKFLFFVL KSSDVLDILV PILFFLNDAR ADQSRVGLMH
IGVFILLLLS GERNFGVRLN KPYSIRVPMD IPVFTGTHAD LLIVVFHKII TSGHQRLQPL
FDCLLTIVVN VSPYLKSLSM VTANKLLHLL EAFSTTWFLF SAAQNHHLVF FLLEVFNNII
QYQFDGNSNL VYAIIRKRSI FHQLANLPTD PPTIHKALQR RRRTPEPLSR TGSQEGTSME
GSRPAAPAEP GTLKTSLVAT PGIDKLTEKS QVSEDGTLRS LEPEPQQSLE DGSPAKGEPS
QAWREQRRPS TSSASGQWSP TPEWVLSWKS KLPLQTIMRL LQVLVPQVEK ICIDKGLTDE
SEILRFLQHG TLVGLLPVPH PILIRKYQAN SGTAMWFRTY MWGVIYLRNV DPPVWYDTDV
KLFEIQRV
