HID1_MOUSE
ID HID1_MOUSE Reviewed; 788 AA.
AC Q8R1F6; A2A6S8; Q8C8V6;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein HID1;
DE AltName: Full=HID1 domain-containing protein;
DE AltName: Full=Protein hid-1 homolog;
GN Name=Hid1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Kikkawa Y., Shitara H., Kohara Y., Takada T., Okamoto M., Taya C.,
RA Wakana S., Kamiya K., Yoshikawa Y., Tokano H., Kitamura K., Shimizu K.,
RA Shiroishi T., Wakabayashi Y., Kominami R., Yonekawa H.;
RT "Mutations in a new protein containing ankyrin repeats and SAM domain cause
RT deafness in Jackson shaker mice, a model for Usher syndrome type IG.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Liver, Lung, and Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane
CC {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Shuttles between the
CC cytosol and the Golgi apparatus. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R1F6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R1F6-2; Sequence=VSP_014474;
CC -!- SIMILARITY: Belongs to the hid-1 family. {ECO:0000305}.
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DR EMBL; AB087506; BAC67686.1; -; mRNA.
DR EMBL; AK044395; BAC31902.1; -; mRNA.
DR EMBL; AL603828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024617; AAH24617.1; -; mRNA.
DR CCDS; CCDS25630.1; -. [Q8R1F6-1]
DR CCDS; CCDS83927.1; -. [Q8R1F6-2]
DR RefSeq; NP_780663.1; NM_175454.2. [Q8R1F6-1]
DR AlphaFoldDB; Q8R1F6; -.
DR BioGRID; 229885; 3.
DR STRING; 10090.ENSMUSP00000102152; -.
DR iPTMnet; Q8R1F6; -.
DR PhosphoSitePlus; Q8R1F6; -.
DR EPD; Q8R1F6; -.
DR jPOST; Q8R1F6; -.
DR MaxQB; Q8R1F6; -.
DR PaxDb; Q8R1F6; -.
DR PRIDE; Q8R1F6; -.
DR ProteomicsDB; 269791; -. [Q8R1F6-1]
DR ProteomicsDB; 269792; -. [Q8R1F6-2]
DR Antibodypedia; 19485; 254 antibodies from 24 providers.
DR DNASU; 217310; -.
DR Ensembl; ENSMUST00000044152; ENSMUSP00000043789; ENSMUSG00000034586. [Q8R1F6-2]
DR Ensembl; ENSMUST00000106542; ENSMUSP00000102152; ENSMUSG00000034586. [Q8R1F6-1]
DR GeneID; 217310; -.
DR KEGG; mmu:217310; -.
DR UCSC; uc007mhg.1; mouse. [Q8R1F6-1]
DR CTD; 283987; -.
DR MGI; MGI:2445087; Hid1.
DR VEuPathDB; HostDB:ENSMUSG00000034586; -.
DR eggNOG; KOG2226; Eukaryota.
DR GeneTree; ENSGT00390000003070; -.
DR HOGENOM; CLU_007392_1_0_1; -.
DR InParanoid; Q8R1F6; -.
DR OMA; GTTAWFR; -.
DR OrthoDB; 319576at2759; -.
DR PhylomeDB; Q8R1F6; -.
DR TreeFam; TF314291; -.
DR BioGRID-ORCS; 217310; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Hid1; mouse.
DR PRO; PR:Q8R1F6; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8R1F6; protein.
DR Bgee; ENSMUSG00000034586; Expressed in lacrimal gland and 164 other tissues.
DR ExpressionAtlas; Q8R1F6; baseline and differential.
DR Genevisible; Q8R1F6; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0090498; C:extrinsic component of Golgi membrane; ISS:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0005797; C:Golgi medial cisterna; ISS:UniProtKB.
DR GO; GO:0000138; C:Golgi trans cisterna; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR InterPro; IPR026705; Hid-1/Ecm30.
DR PANTHER; PTHR21575; PTHR21575; 1.
DR Pfam; PF12722; Hid1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Golgi apparatus; Lipoprotein; Membrane;
KW Myristate; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8IV36"
FT CHAIN 2..788
FT /note="Protein HID1"
FT /id="PRO_0000079297"
FT REGION 297..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 653
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IV36"
FT MOD_RES 670
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 130
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_014474"
FT CONFLICT 332
FT /note="I -> F (in Ref. 2; BAC31902)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 788 AA; 88779 MW; 1C9212C1CD7DDCAA CRC64;
MGSADSKLNF RKAVIQLTTK TQPVEATDNA FWDQFWADTA TSVQDVFALV PAAEIRAVRE
ESPSNLATLC YKAVEKLVQG AEGGCHSEKE KQVVLNCSRL LTRVLPYIFE DPDWRGFFWS
TVPGAGRGGQ GEEEDENARP LAESLLLAIA DLLFCPDFTV QNHRRNDVDS AEDVHSLDSC
EYIWEAGVGF AHSPQPNYIH DMNRMELLKL LLTCFSEAMY LPPSPESGST NPWVQFFCST
ENRHALPLFT SLLNTVCAYD PVGYGIPYNH LLFSDYREPL VEEAAQVLIV TLDHDSATST
SPTVDGTTTG TAMDDADPPG PENLFVNYLS RIHREEDFQF ILKGIARLLS NPLLQTYLPN
STKKIQFHQE LLVLFWKLCD FNKKFLFFVL KSSDVLDILV PILYFLNDAR ADQSRVGLMH
IGVFILLLLS GERNFGVRLN KPYSVRVPMD IPVFTGTHAD LLIVVFHKII TSGHQRLQPL
FDCLLTIVVN VSPYLKSLSM VTANKLLHLL EAFSTTWFLF SASQNHHLVF FLLEVFNNII
QYQFDGNSNL VYAIIRKRAV FHQLANLPTD PPSIHKALQR RRRTPEPLSR TGSQEGTSME
GSRPAAPAEP GTLKTSLVAT PGIDKLTEKS QVSEDGTLRS LEPESQQSSA ENSPSDGESS
QTWREQRRLS NASASGQWSP TSDWILSWKS KLPLQTIMRL LQVLVPQVEK ICIDKGLTDE
SEILRFLQHG TLVGLLPVPH PILIRKYQAN SGTAMWFRTY MWGVIYLRNV DPPIWYDTDV
KLFEIQRV
